Predicted to enable several functions, including ATP binding activity; SH3 domain binding activity; and magnesium ion binding activity. Involved in several processes, including caveola assembly; integrin-mediated signaling pathway; and positive regulation of BMP signaling pathway. Acts upstream of o
r within several processes, including branching involved in ureteric bud morphogenesis; nervous system development; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in focal adhesion and lamellipodium. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and retina. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ILK (integrin linked kinase). [provided by Alliance of Genome Resources, Jul 2025]
7
105385797
105392132
Mouse
457
symbol , old_gene_name , PhenoGen , description , old_gene_symbol
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in regulation of nuclear cell cycle DNA replication and signal transduction. Predicted to be located in cytoplasm. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer
Enables actin binding activity. Involved in several processes, including circulatory system development; smooth muscle cell chemotaxis; and substrate adhesion-dependent cell spreading. Acts upstream of or within cell adhesion. Located in several cellular components, including focal adhesion; lamelli
podium; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PARVA (parvin alpha). [provided by Alliance of Genome Resources, Jul 2025]