Enables identical protein binding activity and ubiquitin binding activity. Involved in ubiquitin-dependent endocytosis. Acts upstream of or within regulation of protein localization. Located in ciliary membrane; clathrin-coated pit; and clathrin-coated vesicle. Part of AP-2 adaptor complex. Is expre
ssed in several structures, including adrenal gland; alimentary system; heart; metanephros; and nervous system. Orthologous to human EPS15 (epidermal growth factor receptor pathway substrate 15). [provided by Alliance of Genome Resources, Jul 2025]
Predicted to enable calcium ion binding activity. Involved in synaptic vesicle endocytosis. Part of clathrin coat of coated pit. Is active in presynapse. Is expressed in several structures, including alimentary system; liver; metanephros; nervous system; and sensory organ. Orthologous to human EPS15