This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein
encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene may produce multiple isoforms by the use of alternative translational start codons. [provided by RefSeq, Mar 2012]
potassium voltage-gated channel, subfamily H (eag-related), member 8
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and delayed rectifier potassium channel activity. Predicted to be involved in negative regulation of apoptotic process; potassium ion transmembrane transport; and regulation of membrane potential. Pred
icted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNH8 (potassium voltage-gated channel subfamily H member 8). [provided by Alliance of Genome Resources, Apr 2025]