This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four st
eps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012]
acyl-Coenzyme A dehydrogenase, short/branched chain
Predicted to enable electron transfer activity; identical protein binding activity; and short-chain 2-methyl fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid metabolic process and isoleucine catabolic process. Predicted to act upstream of or within acyl-CoA metabolic pro
cess. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACADSB (acyl-CoA dehydrogenase short/branched chain). [provided by Alliance of Genome Resources, Apr 2025]