| 1344837 | UFM1 | ubiquitin fold modifier 1 | UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008] | 13 | 38349851 | 38363619 | Human | 147 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 36049837 | UFM1P1 | UFM1 pseudogene 1 | | X | 145768026 | 145769950 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16565636 | UFM1P1 | UFM1 pseudogene 1 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 36049840 | UFM1P2 | UFM1 pseudogene 2 | | 17 | 35375236 | 35377746 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 36049819 | UFM1P3 | UFM1 pseudogene 3 | | 8 | 100164330 | 100165543 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 16559684 | UFM1P3 | UFM1 pseudogene 3 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 1319587 | UFL1 | UFM1 specific ligase 1 | Enables UFM1 ligase activity and protein kinase binding activity. Involved in several processes, including positive regulation of reticulophagy; regulation of intracellular signal transduction; and regulation of primary metabolic process. Acts upstream of or wit hin several processes, including positive regulation of cell population proliferation; regulation of proteasomal ubiquitin-dependent protein catabolic process; and response to endoplasmic reticulum stress. Located in cytoplasm; nucleus; and site of double-strand break. Part of protein-containing complex. Is active in endoplasmic reticulum membrane and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 96521806 | 96555276 | Human | 136 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1604425 | UFSP1 | UFM1 specific peptidase 1 | This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an a ctive form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009] | 7 | 100888721 | 100889715 | Human | 47 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605068 | UFSP2 | UFM1 specific peptidase 2 | This gene encodes a highly conserved cysteine protease. The protein cleaves two C-terminal residues from ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein. Activation of ubiquitin-fold modifier 1 by the encoded protein exposes a C-terminal glycine residue that allows in teraction with other proteins and transfer to its target protein. An allelic variant of this gene has been associated with Beukes hip dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] | 4 | 185399537 | 185425964 | Human | 185 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 16555811 | AC007969.1 | ubiquitin-fold modifier 1 (UFM1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1323296 | UBA5 | ubiquitin like modifier activating enzyme 5 | This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pse udogene of this gene has been identified on chromosome 1. [provided by RefSeq, Feb 2016] | 3 | 132654430 | 132679794 | Human | 224 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1604819 | UFC1 | ubiquitin-fold modifier conjugating enzyme 1 | UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008] | 1 | 161153978 | 161158856 | Human | 146 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1320614 | DDRGK1 | DDRGK domain containing 1 | The protein encoded by this gene interacts with components of the ubiquitin fold modifier 1 conjugation pathway and helps prevent apoptosis in ER-stressed secretory tissues. In addition, the encoded protein regulates nuclear factor-κB activity. [provided by RefSeq, Dec 2015] | 20 | 3190350 | 3204682 | Human | 209 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1316997 | ZUP1 | zinc finger containing ubiquitin peptidase 1 | This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing th e terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018] | 6 | 116635618 | 116668766 | Human | 74 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1322030 | SAYSD1 | SAYSVFN motif domain containing 1 | Enables UFM1-modified protein reader activity. Involved in protein quality control for misfolded or incompletely synthesized proteins and rescue of stalled ribosome. Located in intracellular membrane-bounded organelle. Is active in endoplasmic reticulum. [provid ed by Alliance of Genome Resources, Apr 2025] | 6 | 39104063 | 39115186 | Human | 41 | description | gene, protein-coding, VALIDATED [RefSeq] |
