| 1346082 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012] | 20 | 50081124 | 50115957 | Human | 102 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1603241 | PEDS1-UBE2V1 | PEDS1-UBE2V1 readthrough | The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence s imilarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010] | 20 | 50081124 | 50153723 | Human | 22 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1603242 | PEDS1 | plasmanylethanolamine desaturase 1 | Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] | 20 | 50118254 | 50153723 | Human | 62 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1352007 | UBE2V1P1 | UBE2V1 pseudogene 1 | | 20 | 3360484 | 3362346 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 2301121 | UBE2V1P2 | UBE2V1 pseudogene 2 | INTERACTS WITH lipopolysaccharide | 3 | 175718002 | 175718682 | Human | 1 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 2794509 | UBE2V1P3 | UBE2V1 pseudogene 3 | | Y | 3864609 | 3866758 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10450304 | UBE2V1P4 | UBE2V1 pseudogene 4 | | 9 | 129791196 | 129791837 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7204967 | UBE2V1P5 | UBE2V1 pseudogene 5 | | 10 | 114117108 | 114117557 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7204968 | UBE2V1P6 | UBE2V1 pseudogene 6 | | 2 | 169115195 | 169115674 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10400110 | UBE2V1P7 | UBE2V1 pseudogene 7 | | X | 78554412 | 78554751 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10755388 | UBE2V1P8 | UBE2V1 pseudogene 8 | | 1 | 40942042 | 40942518 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7204951 | UBE2V1P9 | UBE2V1 pseudogene 9 | | X | 90289539 | 90289849 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10401964 | UBE2V1P10 | UBE2V1 pseudogene 10 | | 9 | 85159682 | 85159950 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10755400 | UBE2V1P11 | UBE2V1 pseudogene 11 | | 2 | 201824537 | 201825031 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10400534 | UBE2V1P12 | UBE2V1 pseudogene 12 | | 5 | 18886622 | 18887095 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 11560506 | UBE2V1P13 | UBE2V1 pseudogene 13 | | 1 | 214612761 | 214613413 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 11560508 | UBE2V1P14 | UBE2V1 pseudogene 14 | | 2 | 142543407 | 142544171 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 11560517 | UBE2V1P15 | UBE2V1 pseudogene 15 | | 6 | 75465112 | 75465770 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 32716485 | UBE2V1P16 | UBE2V1 pseudogene 16 | | X | 122010971 | 122030384 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, protein-coding, MODEL [RefSeq] |
| 16556993 | UBE2V1P16 | UBE2V1 pseudogene 16 | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 16560087 | AC022784.4 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16558609 | AC074133.1 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16559624 | AC104986.1 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16561733 | AC245505.1 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16553673 | AL596276.1 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16563866 | AP005136.2 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1315706 | TRAF6 | TNF receptor associated factor 6 | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein has an amino terminal RING domain which is followed by four zinc-fi nger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in antiviral innate and antigen-specific immune responses. [provided by RefSeq, Nov 2021] | 11 | 36483769 | 36510272 | Human | 420 | description | gene, protein-coding, REVIEWED [RefSeq] |
