Tomt Gene Search Result

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3 records found for search term Tomt

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
41410878	TOMT	transmembrane O-methyltransferase	This gene encodes a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness. Readthrough tran ... (more) scription is observed across this gene and the adjacent leucine-rich repeat containing 51 gene. A third locus (GeneID:220074) is defined to represent the readthrough transcripts. [provided by RefSeq, Feb 2021]	11	72105924	72109596	Human	17	symbol , old_gene_name , COSMIC , Human Proteome Map	gene, protein-coding, VALIDATED [RefSeq]
1602965	LRTOMT	leucine rich transmembrane and O-methyltransferase domain containing	This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. The readthrough transcript encodes a fusion protein that s ... (more) hares sequence identity with each individual gene product. Multiple reports implicate mutations in this gene in nonsyndromic deafness.[provided by RefSeq, Feb 2021]	11	72080850	72110782	Human	80	symbol , COSMIC , description , Human Proteome Map , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
41410865	LRRC51	leucine rich repeat containing 51	This gene belongs to the leucine-rich repeat containing family. The encoded protein contains a transmembrane domain and two leucine-rich repeat domains. Unlike in mouse and other mammals, readthrough transcription is observed in primates between this gene and the adjacent transmembrane O-methyltrans ... (more) ferase (Tomt) gene. Previously, this locus was annotated as a single gene representing the readthrough transcripts as well as the two different transcript species that encoded different proteins. It has since been split into three genes, including the two stand-alone genes and a third gene representing the readthrough transcription. [provided by RefSeq, Feb 2022]	11	72080850	72096895	Human	52	description	gene, protein-coding, REVIEWED [RefSeq]