Sorcs3 Gene Search Result

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2 records found for search term Sorcs3

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1322178	SORCS3	sortilin related VPS10 domain containing receptor 3	This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein con ... (more) vertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing. [provided by RefSeq, Dec 2014]	10	104641290	105265242	Human	80	symbol , old_gene_name , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
7241956	SORCS3-AS1	SORCS3 antisense RNA 1	INTERACTS WITH malathion	10	104664608	104666216	Human	1	symbol , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]