Rap1gap Gene Search Result

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3 records found for search term Rap1gap

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1320507	RAP1GAP	RAP1 GTPase activating protein	This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP ... (more) span>, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]	1	21596221	21669357	Human	177	symbol , COSMIC , description , Human Proteome Map , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1346377	RAP1GAP2	RAP1 GTPase activating protein 2	This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript ... (more) variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]	17	2755645	3037741	Human	124	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
16563642	RAP1GAP2-AS1	RAP1GAP2 antisense RNA 1		17	2962247	2965895	Human		symbol , old_gene_name , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]