Ptpn11 Gene Search Result

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13 records found for search term Ptpn11

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
731746	PTPN11	protein tyrosine phosphatase non-receptor type 11	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src ... (more) homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]	12	112418947	112509918	Human	1670	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
38619125	PTPN11P1	PTPN11 pseudogene 1		3	107105314	107107165	Human		symbol , GTEx , COSMIC , name , Human Proteome Map	gene, pseudo, INFERRED [RefSeq]
38611813	PTPN11P2	PTPN11 pseudogene 2		8	58424993	58426850	Human		symbol , GTEx , COSMIC , name , Human Proteome Map	gene, pseudo, INFERRED [RefSeq]
38644343	PTPN11P3	PTPN11 pseudogene 3		6	137705823	137707220	Human		symbol , GTEx , COSMIC , name , Human Proteome Map	gene, pseudo, INFERRED [RefSeq]
38606284	PTPN11P4	PTPN11 pseudogene 4		5	23303963	23305309	Human		symbol , GTEx , COSMIC , name , Human Proteome Map	gene, pseudo, INFERRED [RefSeq]
38672731	PTPN11P5	PTPN11 pseudogene 5		4	82580519	82581384	Human		symbol , GTEx , COSMIC , name , Human Proteome Map	gene, pseudo, INFERRED [RefSeq]
16558048	AC067942.2	Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) pseudogene					Human		name	gene, processed_pseudogene
16558711	AC009927.1	protein tyrosine phosphatase, non-receptor type 11 (PTPN11) pseudogene					Human		name	gene, processed_pseudogene
16558830	AC010460.3	protein tyrosine phosphatase, non-receptor type 11 (PTPN11) pseudogene					Human		name	gene, processed_pseudogene
16557237	AC074043.1	protein tyrosine phosphatase, non-receptor type 11 (PTPN11) pseudogene					Human		name	gene, processed_pseudogene
16552440	AL356234.1	protein tyrosine phosphatase, non-receptor type 11 (PTPN11) pseudogene					Human		name	gene, processed_pseudogene
407570668	PTPN11BP	protein tyrosine phosphatase non-receptor type 11B, pseudogene					Human		symbol , GTEx , COSMIC , Human Proteome Map	gene, pseudo
6893232	LINC00673	long intergenic non-protein coding RNA 673	This gene produces a long non-protein coding RNA that is involved in the regulation of gene expression during tumor progression. This transcript can promote cell proliferation in gastric cancer through interaction with enhancer of zeste 2 and other epigenetic suppressors of gene expression, thereby ... (more) downregulating target genes including Kruppel like factors 2 and 4. This transcript may also act as a tumor suppressor by promoting interaction between protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) and ubiquitin ligase, resulting in degradation of Ptpn11 and lowered oncogenic signalling. Naturally-occurring variation at this locus results in the formation of a binding site for miR-1231, which negatively regulates activity of this transcript. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2017]	17	72403322	72592804	Human	22	description	gene, ncrna, REVIEWED [RefSeq]