Ptbp1 Gene Search Result

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2 records found for search term Ptbp1

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
732339	PTBP1	polypyrimidine tract binding protein 1	This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA pr ... (more) ocessing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]	19	797452	812312	Human	188	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1348128	PTBP1P	polypyrimidine tract binding protein 1 pseudogene		14	65279221	65281655	Human		symbol , COSMIC , Human Proteome Map	gene, pseudo, INFERRED [RefSeq]