Notch4 Gene Search Result

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2 records found for search term Notch4

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1354309	NOTCH4	notch receptor 4	This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple dif ... (more) ferent domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]	6	32194843	32224067	Human	213	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1602888	EGFL7	EGF like domain multiple 7	This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcri ... (more) pt variants. [provided by RefSeq, Feb 2012]	9	136658856	136672678	Human	117	old_gene_name	gene, protein-coding, REVIEWED [RefSeq]