Nalcn Gene Search Result

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6 records found for search term Nalcn

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
733715	NALCN	sodium leak channel, non-selective	This gene encodes a voltage-independent, nonselective cation channel which belongs to a family of voltage-gated sodium and calcium channels that regulates the resting membrane potential and excitability of neurons. This family is expressed throughout the nervous system and conducts a persistent sodi ... (more) um leak current that contributes to tonic neuronal excitability. The encoded protein forms a channelosome complex that includes G-protein-coupled receptors, UNC-79, UNC-80, NCA localization factor-1, and src family tyrosine kinases. Naturally occurring mutations in this gene are associated with infantile neuroaxonal dystrophy, infantile hypotonia with psychomotor retardation and characteristic facies (IHPRF) syndrome, and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD) syndrome. A knockout of the orthologous gene in mice results in paralysis with a severely disrupted respiratory rhythm, and lethality within 24 hours after birth. [provided by RefSeq, Apr 2017]	13	101053776	101417179	Human	292	symbol , old_gene_name , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
6484624	NALCN-AS1	NALCN antisense RNA 1	INTERACTS WITH 4,4'-sulfonyldiphenol; benzo[e]pyrene; bisphenol A	13	100708325	101059286	Human	4	symbol , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]
2293495	NALF1	NALCN channel auxiliary factor 1	Predicted to contribute to stretch-activated, monoatomic cation-selective, calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]	13	107163510	107867496	Human	78	name	gene, protein-coding, VALIDATED [RefSeq]
1350785	NALF2	NALCN channel auxiliary factor 2	This gene encodes a product belonging to a family of proteins with unknown function. The presence of two transmembrane domains suggests that this protein is a multi-pass membrane protein. [provided by RefSeq, Sep 2011]	X	69504326	69532508	Human	52	name	gene, protein-coding, VALIDATED [RefSeq]
1322833	UNC79	unc-79 subunit of NALCN channel complex	The NALCN channel is responsible for Na(+) leak currents. The protein encoded by this gene, along with UNC80, is an accessory subunit of the NALCN channel that contributes to the Ca(2+) sensitivity of the channel. [provided ... (more) by RefSeq, Sep 2016]	14	93333182	93707876	Human	74	old_gene_name , name , description	gene, protein-coding, REVIEWED [RefSeq]
1350674	UNC80	unc-80 subunit of NALCN channel complex	The protein encoded by this gene is a component of a voltage-independent 'leak' ion-channel complex, in which it performs essential functions, such as serving as a bridge between two other components (sodium leak channel non-selective and UNC79) and as a scaffold for Src kinases. Leak channels play ... (more) an importnat role in establishment and maintenance of resting membrane potentials in neurons. Mutations in this gene are associated with congenital infantile encephalopathy, intellectual disability and growth issues. [provided by RefSeq, Aug 2016]	2	209771832	209999296	Human	180	old_gene_name , name	gene, protein-coding, REVIEWED [RefSeq]