Mus81 Gene Search Result

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2 records found for search term Mus81

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1323679	MUS81	MUS81 structure-specific endonuclease subunit	This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA ... (more) double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017]	11	65859674	65867653	Human	125	symbol , old_gene_name , COSMIC , name , description , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1344240	EME2	essential meiotic structure-specific endonuclease subunit 2	EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]	16	1772810	1781702	Human	73	description	gene, protein-coding, VALIDATED [RefSeq]