| 1322332 | ME3 | malic enzyme 3 | Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent i soform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] | 11 | 86434930 | 86672616 | Human | 151 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] | | 14390099 | ME3-DT | ME3 divergent transcript | | 11 | 86672237 | 86753297 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna | | 616940554 | ME3-AS1 | Me3 antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna | | 1323670 | PCDHGA5 | protocadherin gamma subfamily A, 5 | This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008] | 5 | 141364162 | 141512975 | Human | 41 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] | | 16560401 | AP001831.1 | novel transcript, antisense to ME3 | | | | | Human | | name | gene, lncrna | |