Malt1 Gene Search Result

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5 records found for search term Malt1

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1319401	MALT1	MALT1 paracaspase	This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor st ... (more) imulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]	18	58671465	58754477	Human	261	symbol , old_gene_name , COSMIC , name , description , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
16564519	MALT1-AS1	MALT1 antisense RNA 1	INTERACTS WITH cadmium atom; cadmium dichloride; okadaic acid	18	58670009	58671873	Human	3	symbol , old_gene_name , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]
16564663	AC104365.1	novel transcript, antisense to MALT1					Human		name	gene, lncrna
1347575	BCL10	BCL10 immune signaling adaptor	This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with oth ... (more) er CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]	1	85265776	85276632	Human	335	description	gene, protein-coding, REVIEWED [RefSeq]
1351045	CLEC6A	C-type lectin domain containing 6A	The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neo ... (more) formans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]	12	8455962	8478330	Human	96	description	gene, protein-coding, REVIEWED [RefSeq]