Ligatin is a peripheral membrane protein found in mammalian and avian tissues during embryonic development and in early differentiated states. It is a receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery where they participate in specific metabolic processes, as we
ll as intercellular adhesion. Ligatin is, therefore, a trafficking receptor for phosphoglycoproteins (summary by Jakoi et al., 1989 [PubMed 2482295]).[supplied by OMIM, Jan 2011]
This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function