Lgmn Gene Search Result

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2 records found for search term Lgmn

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
731860	LGMN	legumain	This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by aci ... (more) dic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]	14	92703809	92748627	Human	222	symbol , COSMIC , Human Proteome Map , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1346654	LGMNP1	legumain pseudogene 1		13	64957561	64959518	Human		symbol , COSMIC , Human Proteome Map , old_gene_symbol	gene, pseudo, INFERRED [RefSeq]