This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 20
This locus represents naturally occurring readthrough transcription between the neighboring SLC35D2 (solute carrier family 35 member D2) and HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3) genes on chromosome 9. The readthrough transcript is a candidate for non