Hlf Gene Search Result

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8 records found for search term Hlf

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1347027	HLF	HLF transcription factor, PAR bZIP family member	This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal transloc ... (more) ations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]	17	55264960	55325187	Human	179	symbol , old_gene_name , COSMIC , name , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
617301382	HLF-AS1	HLF antisense RNA 1					Human		symbol , GTEx , COSMIC , name , Human Proteome Map	gene, ncrna
68594	EPAS1	endothelial PAS domain protein 1	This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways whic ... (more) h respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]	2	46297407	46386697	Human	544	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
6481576	HLFP1	HLF pseudogene 1		6	132674885	132675383	Human		symbol , COSMIC , name , Human Proteome Map	gene, pseudo, INFERRED [RefSeq]
16563677	AC007638.2	novel transcript, antisense to HLF					Human		name	gene, lncrna
1342616	CFHR3	complement factor H related 3	The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an incre ... (more) ased risk of atypical hemolytic-uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]	1	196774840	196795407	Human	110	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1313477	LTF	lactotransferrin	This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune syst ... (more) em. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Activity against both DNA and RNA viruses has been found, including activity against SARS-CoV-2, and HIV. [provided by RefSeq, Jul 2021]	3	46435645	46485234	Human	278	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1345103	TEF	TEF transcription factor, PAR bZIP family member	This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to ... (more) the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]	22	41367455	41399326	Human	176	description	gene, protein-coding, REVIEWED [RefSeq]