Fbxo32 Gene Search Result

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1 records found for search term Fbxo32

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
734419	FBXO32	F-box protein 32	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependen ... (more) t ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]	8	123497889	123541206	Human	267	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]