| 1352961 | ECI1 | enoyl-CoA delta isomerase 1 | This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, an d polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010] | 16 | 2239402 | 2251587 | Human | 212 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 16563384 | ECI1-AS1 | ECI1 antisense RNA 1 | | | | | Human | | old_gene_name | gene, lncrna |
| 1352867 | CLEC4A | C-type lectin domain family 4 member A | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The enco ded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] | 12 | 8102907 | 8138607 | Human | 115 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1318099 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndr ome. [provided by RefSeq, Mar 2010] | 20 | 36889773 | 36951708 | Human | 395 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1602051 | CXCL17 | C-X-C motif chemokine ligand 17 | The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Sa lmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015] | 19 | 42428278 | 42442946 | Human | 81 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 732077 | PSMC3 | proteasome 26S subunit, ATPase 3 | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. T he 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008] | 11 | 47418775 | 47426439 | Human | 209 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |