Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synt
hase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
ENCODES a pseudogene that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); INTERACTS WITH 2-hydroxypropanoic acid; methylmercury chloride; propanal
16
29863683
29868053
Human
12
symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol