Cblb Gene Search Result

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2 records found for search term Cblb

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
733798	CBLB	Cbl proto-oncogene B	This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, ... (more) and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]	3	105655461	105869449	Human	269	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1347796	MMAB	metabolism of cobalamin associated B	This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complem ... (more) entation group. Alternatively spliced transcript variants have been found. [provided by RefSeq, Apr 2011]	12	109553715	109573504	Human	267	old_gene_name , description , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]