| 1313737 | ADGRB1 | adhesion G protein-coupled receptor B1 | Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008] | 8 | 142449649 | 142545007 | Human | 163 | description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1318052 | BAIAP3 | BAI1 associated protein 3 | This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] | 16 | 1333645 | 1349439 | Human | 100 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 16565519 | AC009501.1 | BAI1-associated protein 2-like 1 (BAIAP2L1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 732926 | BAIAP2 | BAR/IMD domain containing adaptor protein 2 | The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009] | 17 | 81035151 | 81117434 | Human | 267 | old_gene_name , description , ensembl_full_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1322871 | MAGI1 | membrane associated guanylate kinase, WW and PDZ domain containing 1 | The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a rol e as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] | 3 | 65353526 | 66038918 | Human | 160 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1352215 | BAIAP2L1 | BAR/IMD domain containing adaptor protein 2 like 1 | This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009] | 7 | 98291650 | 98401090 | Human | 136 | old_gene_name , ensembl_full_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1342805 | BAIAP2L2 | BAR/IMD domain containing adaptor protein 2 like 2 | The protein encoded by this gene binds phosphoinositides and promotes the formation of planar or curved membrane structures. The encoded protein is found in RAB13-positive vesicles and at intercellular contacts with the plasma membrane. [provided by RefSeq, Dec 2012] | 22 | 38084900 | 38110967 | Human | 73 | old_gene_name , ensembl_full_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1320187 | ADGRB3 | adhesion G protein-coupled receptor B3 | This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have sim ilar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008] | 6 | 68635282 | 69389506 | Human | 95 | description | gene, protein-coding, REVIEWED [RefSeq] |
