| 1322201 | ABHD1 | abhydrolase domain containing 1 | This gene is a member of the AB hydrolase superfamily and encodes a protein with an alpha/beta hydrolase fold. This domain is common to a number of hydrolytic enzymes of widely differing phylogenetic origins and catalytic functions. [provided by RefSeq, Jul 2008] | 2 | 27123815 | 27130812 | Human | 92 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1346003 | ABHD10 | abhydrolase domain containing 10, depalmitoylase | This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] | 3 | 111979026 | 111993368 | Human | 83 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1606493 | ABHD11 | abhydrolase domain containing 11 | This gene encodes a protein containing an alpha/beta hydrolase fold domain. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. [provided by RefSeq, Mar 2016] | 7 | 73736094 | 73738802 | Human | 97 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1314604 | ABHD12 | abhydrolase domain containing 12, lysophospholipase | This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, moo d, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011] | 20 | 25294743 | 25390835 | Human | 210 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1318018 | ABHD13 | abhydrolase domain containing 13 | Predicted to enable palmitoyl-(protein) hydrolase activity. Predicted to be involved in protein depalmitoylation. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025] | 13 | 108218392 | 108234243 | Human | 57 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1605591 | ABHD15 | abhydrolase domain containing 15 | Predicted to enable monoacylglycerol lipase activity and short-chain carboxylesterase activity. Predicted to be involved in adipose tissue development and lipid catabolic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 29560547 | 29567037 | Human | 95 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1604791 | ABHD18 | abhydrolase domain containing 18 | Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 127965406 | 128039953 | Human | 33 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1349841 | ABHD12B | abhydrolase domain containing 12B | Predicted to enable lysophospholipase activity and monoacylglycerol lipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025] | 14 | 50872053 | 50904970 | Human | 33 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1601874 | ABHD14A | abhydrolase domain containing 14A | Predicted to enable hydrolase activity. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 51975064 | 51981196 | Human | 77 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1603002 | ABHD14B | abhydrolase domain containing 14B | Enables hydrolase activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 51968510 | 51974630 | Human | 120 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1351609 | ABHD16A | abhydrolase domain containing 16A, phospholipase | A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some as pects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010] | 6 | 31686955 | 31703324 | Human | 122 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1320221 | ABHD16B | abhydrolase domain containing 16B | Predicted to enable monoacylglycerol lipase activity and phospholipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 63861498 | 63862988 | Human | 28 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1347246 | ABHD17A | abhydrolase domain containing 17A, depalmitoylase | Enables palmitoyl-(protein) hydrolase activity. Involved in negative regulation of NLRP3 inflammasome complex assembly; protein depalmitoylation; and protein localization to membrane. Located in endosome membrane; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Jul 202 5] | 19 | 1876810 | 1885496 | Human | 104 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1313162 | ABHD17B | abhydrolase domain containing 17B, depalmitoylase | Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 71862452 | 71911193 | Human | 99 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1603613 | ABHD17C | abhydrolase domain containing 17C, depalmitoylase | Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Predicted to be located in dendritic spine; postsynaptic density membrane; and recycling endosome membrane. Predicted to be active in endosome membrane; glutamatergic synapse; and plasma membrane. [provided by Alli ance of Genome Resources, Apr 2025] | 15 | 80695310 | 80755621 | Human | 72 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1604668 | ABHD17AP1 | ABHD17A pseudogene 1 | INTERACTS WITH temozolomide | 1 | 148146066 | 148149788 | Human | 1 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 2292190 | ABHD17AP3 | ABHD17A pseudogene 3 | | 1 | 214605457 | 214609203 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 2293157 | ABHD17AP4 | ABHD17A pseudogene 4 | INTERACTS WITH resveratrol | 22 | 20667597 | 20671339 | Human | 1 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 3520891 | ABHD17AP5 | ABHD17A pseudogene 5 | This locus is a pseudogene in the FAM108 family, and lies in the immunoglobulin lambda gene cluster on chromosome 22q11.21. [provided by RefSeq, Jun 2010] | 22 | 22117481 | 22118005 | Human | 3 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 3378585 | ABHD17AP6 | ABHD17A pseudogene 6 | | 17 | 20840687 | 20844479 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 3207450 | ABHD17AP7 | ABHD17A pseudogene 7 | | 16 | 32726412 | 32729540 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 2859282 | ABHD17AP8 | ABHD17A pseudogene 8 | | 16 | 32199899 | 32203021 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 3418290 | ABHD17AP9 | ABHD17A pseudogene 9 | | 16 | 33140868 | 33144023 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 9588876 | ABHD15-AS1 | ABHD15 antisense RNA 1 | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna |
| 38643283 | ABHD16B-AS1 | ABHD16B antisense RNA 1 | | 20 | 63861215 | 63865073 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 5133081 | ABHD14A-ACY1 | ABHD14A-ACY1 readthrough | This locus represents naturally occurring read-through transcription between the neighboring abhydrolase domain containing 14A (ABHD14A) and aminoacylase 1 (ACY1) genes on chromosome 3. The read-through transcript encodes a protein that shares sequence identity with the downstream gene product but its N-terminal region is distinct due to the use of an alternate start codon relative to the upstream gene. [provided by RefSeq, Oct 2015] | 3 | 51975064 | 51989197 | Human | 20 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1342590 | BICDL3P | BICD family like 3, pseudogene | INTERACTS WITH cadmium dichloride; cisplatin; propofol | 7 | 73735069 | 73736000 | Human | 12 | old_gene_name , old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 1352675 | PREB | prolactin regulatory element binding | This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008] | 2 | 27130756 | 27134636 | Human | 125 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 16566081 | AC023141.13 | abhydrolase domain containing 15 (ABHD15) pseudogene | | 7 | 57835336 | 57836252 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16565736 | AL512430.4 | abhydrolase domain containing 10 (ABHD10) pseudogene | | 6 | 110598104 | 110598689 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16568590 | AC116165.3 | abhydrolase domain containing 17A (ABHD17A) pseudogene | | 15 | 23225888 | 23226392 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16563232 | AC138749.4 | glypican 5 (GPC5) pseudogene | | 15 | 28454624 | 28484813 | Human | | old_gene_name | gene, pseudo, MODEL [RefSeq] |
| 16565064 | AL118506.1 | uncharacterized LOC112268269 | | | | | Human | | old_gene_name | gene, lncrna |
| 1351880 | ACY1 | aminoacylase 1 | This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region r educed to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010] | 3 | 51983535 | 51989197 | Human | 171 | description | gene, protein-coding, REVIEWED [RefSeq] |
