ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN embryonic body morphogenesis (ortho
log); negative regulation of DNA-templated transcription (ortholog); negative regulation of gene expression (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic body morphogenesis and stem cell differentiation. Predicted to be located in nucleoplasm. Is expressed in several
structures, including branchial arch; egg cylinder; genitourinary system; immune system; and intestine. Orthologous to human ZNF281 (zinc finger protein 281). [provided by Alliance of Genome Resources, Jul 2025]