| 1351169 | ZBTB33 | zinc finger and BTB domain containing 33 | This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repres sor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010] | X | 120250812 | 120258398 | Human | 88 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557407 | Zbtb33 | zinc finger and BTB domain containing 33 | Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regula tion of cytokine production; and regulation of immune system process. Predicted to act upstream of or within DNA-templated transcription. Located in nucleus. Is expressed in several structures, including bladder; central nervous system; early conceptus; eye; and gonad. Orthologous to human ZBTB33 (zinc finger and BTB domain containing 33). [provided by Alliance of Genome Resources, Jul 2025] | X | 37278670 | 37285923 | Mouse | 91 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1566309 | Zbtb33 | zinc finger and BTB domain containing 33 | ENCODES a protein that exhibits methyl-CpG binding (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN DNA modification pathway; FOUND IN cytosol (or tholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate; bisphenol A | X | 121828960 | 121836193 | Rat | 79 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9061393 | Zbtb33 | zinc finger and BTB domain containing 33 | ENCODES a protein that exhibits methyl-CpG binding (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN DNA modification pathway; FOUND IN cytosol (or tholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955572 | 1628263 | 1636299 | Chinchilla | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11791876 | ZBTB33 | zinc finger and BTB domain containing 33 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); regulation of tra nscription by RNA polymerase II (inferred); PARTICIPATES IN DNA modification pathway; FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | X | 109521333 | 109530467 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12137357 | ZBTB33 | zinc finger and BTB domain containing 33 | ENCODES a protein that exhibits DNA binding (inferred); metal ion binding (inferred); methyl-CpG binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); Wnt signaling pathway (inferred); PARTICIPATES IN DNA modification p athway; FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | X | 92243159 | 92250940 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12704760 | Zbtb33 | zinc finger and BTB domain containing 33 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); regulation of tra nscription by RNA polymerase II (inferred); PARTICIPATES IN DNA modification pathway; FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936479 | 9781923 | 9791000 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249582 | zbtb33 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18902212 | Zbtb33 | zinc finger and BTB domain containing 33 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); regulation of tra nscription by RNA polymerase II (inferred); PARTICIPATES IN DNA modification pathway; FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13963878 | ZBTB33 | zinc finger and BTB domain containing 33 | ENCODES a protein that exhibits DNA binding (inferred); metal ion binding (inferred); methyl-CpG binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); Wnt signaling pathway (inferred); PARTICIPATES IN DNA modification p athway; FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625851280 | Zbtb33 | zinc finger and BTB domain containing 33 | ENCODES a protein that exhibits methyl-CpG binding (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN DNA modification pathway; FOUND IN cytosol (or tholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18569131 | ZBTB33 | zinc finger and BTB domain containing 33 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); regulation of tra nscription by RNA polymerase II (inferred); PARTICIPATES IN DNA modification pathway; FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254010 | zbtb33.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248847 | zbtb33.S | | | | | | African Clawed Frog | | symbol | gene, null |