| 1306121 | Vps72 | vacuolar protein sorting 72 homolog | ENCODES a protein that exhibits histone binding (ortholog); histone chaperone activity (ortholog); INVOLVED IN positive regulation of double-strand break repair via homologous recombination (ortholog); regulation of cell cycle (ortholog); somatic stem cell population maintenance (ortholog); PARTICIP ATES IN INO80 family mediated chromatin remodeling pathway; FOUND IN nuclear speck (ortholog); protein-containing complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol | 2 | 185367329 | 185379199 | Rat | 82 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1314551 | VPS72 | vacuolar protein sorting 72 homolog | The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, dou ble strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012] | 1 | 151176304 | 151190197 | Human | 88 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1619245 | Vps72 | vacuolar protein sorting 72 | Enables histone binding activity. Acts upstream of or within somatic stem cell population maintenance. Predicted to be located in nuclear speck. Predicted to be part of NuA4 histone acetyltransferase complex and nucleosome. Predicted to be active in nucleus. Is expressed in several structures, inclu ding branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human VPS72 (vacuolar protein sorting 72 homolog). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 95018353 | 95030362 | Mouse | 103 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8833427 | Vps72 | vacuolar protein sorting 72 homolog | ENCODES a protein that exhibits histone binding (ortholog); histone chaperone activity (ortholog); INVOLVED IN positive regulation of double-strand break repair via homologous recombination (ortholog); regulation of cell cycle (ortholog); somatic stem cell population maintenance (ortholog); PARTICIP ATES IN INO80 family mediated chromatin remodeling pathway; FOUND IN NuA4 histone acetyltransferase complex (ortholog); nuclear speck (ortholog); nucleosome (ortholog) | NW_004955588 | 537122 | 550564 | Chinchilla | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11902534 | VPS72 | vacuolar protein sorting 72 homolog | ENCODES a protein that exhibits histone binding (inferred); histone chaperone activity (inferred); INVOLVED IN somatic stem cell population maintenance (ortholog); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; FOUND IN nuclear speck (inferred); nucleus (inferred); protein-conta ining complex (inferred) | 1 | 126525642 | 126539432 | Bonobo | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12429933 | VPS72 | vacuolar protein sorting 72 homolog | ENCODES a protein that exhibits histone binding (inferred); histone chaperone activity (inferred); INVOLVED IN somatic stem cell population maintenance (ortholog); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; FOUND IN nuclear speck (inferred); protein-containing complex (infer red) | 17 | 60239299 | 60252323 | Dog | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12720904 | Vps72 | vacuolar protein sorting 72 homolog | ENCODES a protein that exhibits histone binding (inferred); histone chaperone activity (inferred); INVOLVED IN somatic stem cell population maintenance (ortholog); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; FOUND IN nuclear speck (inferred); nucleus (inferred); protein-conta ining complex (inferred) | NW_004936580 | 1381454 | 1395319 | Squirrel | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14389188 | VPS72 | | | | | | Yeast | | symbol | gene, null |
| 284419901 | vps72 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18902602 | Vps72 | vacuolar protein sorting 72 homolog | ENCODES a protein that exhibits histone binding (ortholog); histone chaperone activity (ortholog); INVOLVED IN positive regulation of double-strand break repair via homologous recombination (ortholog); regulation of cell cycle (ortholog); somatic stem cell population maintenance (ortholog); PARTICIP ATES IN INO80 family mediated chromatin remodeling pathway; FOUND IN NuA4 histone acetyltransferase complex (ortholog); nuclear speck (ortholog); nucleosome (ortholog) | | | | Naked Mole-Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14020915 | VPS72 | vacuolar protein sorting 72 homolog | ENCODES a protein that exhibits histone binding (inferred); histone chaperone activity (inferred); INVOLVED IN somatic stem cell population maintenance (ortholog); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; FOUND IN nuclear speck (inferred); protein-containing complex (infer red); INTERACTS WITH deoxynivalenol | | | | Pig | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18634734 | VPS72 | vacuolar protein sorting 72 homolog | ENCODES a protein that exhibits histone binding (inferred); histone chaperone activity (inferred); INVOLVED IN somatic stem cell population maintenance (ortholog); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; FOUND IN nuclear speck (inferred); nucleus (inferred); protein-conta ining complex (inferred) | | | | Green Monkey | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625960426 | Vps72 | vacuolar protein sorting 72 homolog | ENCODES a protein that exhibits histone binding (ortholog); histone chaperone activity (ortholog); INVOLVED IN positive regulation of double-strand break repair via homologous recombination (ortholog); regulation of cell cycle (ortholog); somatic stem cell population maintenance (ortholog); PARTICIP ATES IN INO80 family mediated chromatin remodeling pathway; FOUND IN NuA4 histone acetyltransferase complex (ortholog); nuclear speck (ortholog); nucleosome (ortholog) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286127682 | vps72.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284420202 | vps72.S | | | | | | African Clawed Frog | | symbol | gene, null |
