| 1307806 | Upk1b | uroplakin 1B | INVOLVED IN epithelial cell differentiation (ortholog); response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); apical plasma membrane urothelial plaque (ortholog); INTERACTS WITH 17beta-estradiol; acetamide; acrylamide | 11 | 75459244 | 75496579 | Rat | 67 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1317213 | UPK1B | uroplakin 1B | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008] | 3 | 119173598 | 119205143 | Human | 71 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1623269 | Upk1b | uroplakin 1B | Acts upstream of or within response to bacterium. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in genitourinary system; mesothelium; pharyngo-tympanic tube; pharynx epithelium; and skin. Orthologous to human UPK1B 1B (uroplakin 1B). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 38593544 | 38620565 | Mouse | 70 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9062314 | Upk1b | uroplakin 1B | INVOLVED IN epithelial cell differentiation (ortholog); response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); apical plasma membrane urothelial plaque (ortholog) | NW_004955427 | 18929125 | 18959745 | Chinchilla | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11974219 | UPK1B | uroplakin 1B | INVOLVED IN response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (inferred); apical plasma membrane urothelial plaque (inferred); membrane (inferred) | 3 | 116291573 | 116323014 | Bonobo | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12339351 | UPK1B | uroplakin 1B | INVOLVED IN response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (inferred); apical plasma membrane urothelial plaque (inferred); membrane (inferred) | 33 | 22866672 | 22896268 | Dog | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12453894 | Upk1b | uroplakin 1B | INVOLVED IN response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (inferred); apical plasma membrane urothelial plaque (inferred); membrane (inferred) | NW_004936536 | 6178159 | 6208273 | Squirrel | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934843 | Upk1b | uroplakin 1B | INVOLVED IN epithelial cell differentiation (ortholog); response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); apical plasma membrane urothelial plaque (ortholog) | | | | Naked Mole-Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626131690 | Upk1b | uroplakin 1B | INVOLVED IN epithelial cell differentiation (ortholog); response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); apical plasma membrane urothelial plaque (ortholog) | | | | Black Rat | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14182665 | UPK1B | uroplakin 1B | INVOLVED IN response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (inferred); apical plasma membrane urothelial plaque (inferred); membrane (inferred); INTERACTS WITH deoxynivalenol; zearalenone | | | | Pig | 12 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18604272 | UPK1B | uroplakin 1B | INVOLVED IN response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (inferred); apical plasma membrane urothelial plaque (inferred); membrane (inferred) | | | | Green Monkey | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245610 | upk1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155236822 | upk1b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241408 | upk1b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16559097 | AC083800.1 | novel chromosome 3 open reading frame 30 (C3orf30) and uroplakin 1B (UPK1B) | | | | | Human | | name | gene, protein-coding |
| 1320049 | UPK3B | uroplakin 3B | UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial p laques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM, Mar 2008] | 7 | 76510552 | 76516522 | Human | 52 | description | gene, protein-coding, VALIDATED [RefSeq] |