| 1305503 | Ube2v1 | ubiquitin conjugating enzyme E2 V1 | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN regulation protein catabolic process at postsynapse; error-free postreplication DNA repair (ortholog); positive regulation of canonical NF-kappaB signal tran sduction (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; FOUND IN glutamatergic synapse; postsynaptic density; cytoplasm (ortholog); INTERACTS WITH bisphenol A; decabromodiphenyl ether; flutamide | 3 | 176736325 | 176759174 | Rat | 89 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1313569 | Ube2v1 | ubiquitin-conjugating enzyme E2 variant 1 | Enables ubiquitin conjugating enzyme binding activity. Contributes to ubiquitin conjugating enzyme activity. Acts upstream of or within error-free postreplication DNA repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of UBC13-MMS2 complex and ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human UBE2V1 (ubiquitin conjugating enzyme E2 V1). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 167449559 | 167473933 | Mouse | 105 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1346082 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012] | 20 | 50081124 | 50115957 | Human | 102 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8936803 | Ube2v1 | ubiquitin conjugating enzyme E2 V1 | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN error-free postreplication DNA repair (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of intracell ular signal transduction (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | NW_004955445 | 8142882 | 8174199 | Chinchilla | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11692878 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN error-free postreplication DNA repair (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of intracell ular signal transduction (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | 20 | 46422383 | 46457295 | Bonobo | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12364849 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (inferred); ubiquitin conjugating enzyme binding (inferred); INVOLVED IN error-free postreplication DNA repair (ortholog); regulation protein catabolic process at postsynapse (ortholog); PARTICIPATES IN interleukin-1 signaling pat hway; Toll-like receptor signaling pathway; FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | 24 | 36570172 | 36601200 | Dog | 33 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 14169073 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN error-free postreplication DNA repair (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of intracell ular signal transduction (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 33 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18474335 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN error-free postreplication DNA repair (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of intracell ular signal transduction (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | | | | Green Monkey | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18905247 | Ube2v1 | ubiquitin conjugating enzyme E2 V1 | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN error-free postreplication DNA repair (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of intracell ular signal transduction (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233629 | ube2v1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625949106 | Ube2v1 | ubiquitin conjugating enzyme E2 V1 | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN error-free postreplication DNA repair (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of intracell ular signal transduction (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236461 | ube2v1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155233630 | ube2v1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6489815 | Ube2v1-ps1 | ubiquitin conjugating enzyme E2 V1, pseudogene 1 | | 12 | 395530 | 397284 | Rat | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 2318741 | Ube2v1-ps2 | ubiquitin conjugating enzyme E2 V1, pseudogene 2 | | | | | Rat | | symbol , PhenoGen | gene, pseudo |
| 40947202 | Ube2v1-ps3 | ubiquitin conjugating enzyme E2 V1, pseudogene 3 | | 16 | 52246773 | 52247934 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 40982487 | Ube2v1-ps4 | ubiquitin conjugating enzyme E2 V1, pseudogene 4 | | 2 | 3425539 | 3425984 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41364365 | Ube2v1-ps5 | ubiquitin conjugating enzyme E2 V1, pseudogene 5 | | 2 | 3224903 | 3225568 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 40940920 | Ube2v1-ps6 | ubiquitin conjugating enzyme E2 V1, pseudogene 6 | | 2 | 5126700 | 5127205 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41010086 | Ube2v1-ps10 | ubiquitin conjugating enzyme E2 V1, pseudogene 10 | | 3 | 23345475 | 23347679 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41056690 | Ube2v1-ps11 | ubiquitin conjugating enzyme E2 V1, pseudogene 11 | | 3 | 24267467 | 24268234 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41235420 | Ube2v1-ps12 | ubiquitin conjugating enzyme E2 V1, pseudogene 12 | | 4 | 201239 | 201915 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1595622 | Ube2v1-ps13 | ubiquitin conjugating enzyme E2 V1, pseudogene 13 | | 3 | 23296875 | 23298669 | Rat | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 41180048 | Ube2v1-ps14 | ubiquitin conjugating enzyme E2 V1, pseudogene 14 | | 10 | 694627 | 695409 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41131101 | Ube2v1-ps15 | ubiquitin conjugating enzyme E2 V1, pseudogene 15 | | 2 | 4372338 | 4373274 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41275654 | Ube2v1-ps16 | ubiquitin conjugating enzyme E2 V1, pseudogene 16 | | 2 | 1956155 | 1970992 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41231670 | Ube2v1-ps18 | ubiquitin conjugating enzyme E2 V1, pseudogene 18 | | 4 | 490465 | 491401 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1585838 | Ube2v1-ps20 | ubiquitin conjugating enzyme E2 V1, pseudogene 20 | | 2 | 32980819 | 32981753 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1597741 | Ube2v1-ps21 | ubiquitin conjugating enzyme E2 V1, pseudogene 21 | | 8 | 105856020 | 105857438 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1586396 | Ube2v1-ps22 | ubiquitin conjugating enzyme E2 V1, pseudogene 22 | | 9 | 41129806 | 41130261 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1590940 | Ube2v1-ps23 | ubiquitin conjugating enzyme E2 V1, pseudogene 23 | | 4 | 4516409 | 4516871 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 6500747 | Ube2v1-ps24 | ubiquitin conjugating enzyme E2 V1, pseudogene 24 | | 11 | 881185 | 881788 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 7513228 | Ube2v1-ps26 | ubiquitin conjugating enzyme E2 V1, pseudogene 26 | | 3 | 21288968 | 21289795 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1603241 | PEDS1-UBE2V1 | PEDS1-UBE2V1 readthrough | The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence s imilarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010] | 20 | 50081124 | 50153723 | Human | 22 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 12514018 | LOC101977921 | ubiquitin-conjugating enzyme E2 variant 1 | ENCODES a protein that exhibits ubiquitin conjugating enzyme activity (ortholog); ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN error-free postreplication DNA repair (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); positive regulation of intracell ular signal transduction (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); glutamatergic synapse (ortholog) | NW_004936514 | 4382428 | 4405151 | Squirrel | 30 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1603242 | PEDS1 | plasmanylethanolamine desaturase 1 | Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] | 20 | 50118254 | 50153723 | Human | 62 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 20867130 | PEDS1 | plasmanylethanolamine desaturase 1 | ENCODES a protein that exhibits oxidoreductase activity (inferred); plasmanylethanolamine desaturase activity (inferred); INVOLVED IN ether lipid biosynthetic process (inferred); fatty acid metabolic process (inferred); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (infer red); membrane (inferred) | | | | Green Monkey | 10 | old_gene_name , old_gene_symbol | gene, protein-coding |
| 1352007 | UBE2V1P1 | UBE2V1 pseudogene 1 | | 20 | 3360484 | 3362346 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 2301121 | UBE2V1P2 | UBE2V1 pseudogene 2 | INTERACTS WITH lipopolysaccharide | 3 | 175718002 | 175718682 | Human | 1 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 2794509 | UBE2V1P3 | UBE2V1 pseudogene 3 | | Y | 3864609 | 3866758 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10450304 | UBE2V1P4 | UBE2V1 pseudogene 4 | | 9 | 129791196 | 129791837 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7204967 | UBE2V1P5 | UBE2V1 pseudogene 5 | | 10 | 114117108 | 114117557 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7204968 | UBE2V1P6 | UBE2V1 pseudogene 6 | | 2 | 169115195 | 169115674 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10400110 | UBE2V1P7 | UBE2V1 pseudogene 7 | | X | 78554412 | 78554751 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10755388 | UBE2V1P8 | UBE2V1 pseudogene 8 | | 1 | 40942042 | 40942518 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7204951 | UBE2V1P9 | UBE2V1 pseudogene 9 | | X | 90289539 | 90289849 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10401964 | UBE2V1P10 | UBE2V1 pseudogene 10 | | 9 | 85159682 | 85159950 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10755400 | UBE2V1P11 | UBE2V1 pseudogene 11 | | 2 | 201824537 | 201825031 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10400534 | UBE2V1P12 | UBE2V1 pseudogene 12 | | 5 | 18886622 | 18887095 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 11560506 | UBE2V1P13 | UBE2V1 pseudogene 13 | | 1 | 214612761 | 214613413 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 11560508 | UBE2V1P14 | UBE2V1 pseudogene 14 | | 2 | 142543407 | 142544171 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 11560517 | UBE2V1P15 | UBE2V1 pseudogene 15 | | 6 | 75465112 | 75465770 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16556993 | UBE2V1P16 | UBE2V1 pseudogene 16 | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 32716485 | UBE2V1P16 | UBE2V1 pseudogene 16 | | X | 122010971 | 122030384 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, protein-coding, MODEL [RefSeq] |
| 16560087 | AC022784.4 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16558609 | AC074133.1 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16559624 | AC104986.1 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16561733 | AC245505.1 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16553673 | AL596276.1 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16563866 | AP005136.2 | ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1587144 | Ube2v1l1 | ubiquitin conjugating enzyme E2 V1 like 1 | INVOLVED IN regulation protein catabolic process at postsynapse; FOUND IN glutamatergic synapse; postsynaptic density | 14 | 5007958 | 5009677 | Rat | 9 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 2323508 | Ube2v1l2 | ubiquitin conjugating enzyme E2 V1 like 2 | | 15 | 47309441 | 47310019 | Rat | | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1315706 | TRAF6 | TNF receptor associated factor 6 | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein has an amino terminal RING domain which is followed by four zinc-fi nger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in antiviral innate and antigen-specific immune responses. [provided by RefSeq, Nov 2021] | 11 | 36483769 | 36510272 | Human | 420 | description | gene, protein-coding, REVIEWED [RefSeq] |