| 1350727 | TRIM24 | tripartite motif containing 24 | The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromat in and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] | 7 | 138460259 | 138589996 | Human | 208 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1560596 | Trim24 | tripartite motif-containing 24 | ENCODES a protein that exhibits chromatin binding (ortholog); estrogen response element binding (ortholog); histone H3K23ac reader activity (ortholog); INVOLVED IN response to peptide hormone; calcium ion homeostasis (ortholog); cellular response to estrogen stimulus (ortholog); PARTICIPATES IN hist one modification pathway; retinoic acid signaling pathway; ASSOCIATED WITH castration-resistant prostate carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (ortholog); euchromatin (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 4 | 67534240 | 67659014 | Rat | 221 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1615938 | Trim24 | tripartite motif-containing 24 | The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and bin ding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013] | 6 | 37846816 | 37945380 | Mouse | 224 | symbol , old_gene_name , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8844817 | Trim24 | tripartite motif containing 24 | ENCODES a protein that exhibits chromatin binding (ortholog); estrogen response element binding (ortholog); histone H3K23ac reader activity (ortholog); INVOLVED IN calcium ion homeostasis (ortholog); cellular response to estrogen stimulus (ortholog); negative regulation of cell population proliferat ion (ortholog); PARTICIPATES IN histone modification pathway; retinoic acid signaling pathway; ASSOCIATED WITH castration-resistant prostate carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (ortholog); euchromatin (ortholog); nucleoplasm (ortholog) | NW_004955494 | 4308924 | 4421588 | Chinchilla | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11954974 | TRIM24 | tripartite motif containing 24 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); estrogen response element binding (inferred); INVOLVED IN calcium ion homeostasis (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of DNA-templated transcription (ort holog); PARTICIPATES IN histone modification pathway; retinoic acid signaling pathway; ASSOCIATED WITH castration-resistant prostate carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); hepatocellular carcinoma (ortholog); FOUND IN chromatin (inferred); cytoplasm (inferred); euchromatin (inferred) | 7 | 130420334 | 130547489 | Bonobo | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12077172 | TRIM24 | tripartite motif containing 24 | ENCODES a protein that exhibits chromatin binding (ortholog); estrogen response element binding (ortholog); histone H3K23ac reader activity (ortholog); INVOLVED IN calcium ion homeostasis (ortholog); cellular response to estrogen stimulus (ortholog); negative regulation of cell population proliferat ion (ortholog); PARTICIPATES IN histone modification pathway; retinoic acid signaling pathway; ASSOCIATED WITH castration-resistant prostate carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (ortholog); euchromatin (ortholog); nucleoplasm (ortholog) | 16 | 10033993 | 10133450 | Dog | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12485173 | Trim24 | tripartite motif containing 24 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); estrogen response element binding (inferred); INVOLVED IN calcium ion homeostasis (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of DNA-templated transcription (ort holog); PARTICIPATES IN histone modification pathway; retinoic acid signaling pathway; ASSOCIATED WITH castration-resistant prostate carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); hepatocellular carcinoma (ortholog); FOUND IN chromatin (inferred); cytoplasm (inferred); euchromatin (inferred) | NW_004936592 | 2902805 | 2962602 | Squirrel | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18924406 | Trim24 | tripartite motif containing 24 | ENCODES a protein that exhibits chromatin binding (ortholog); estrogen response element binding (ortholog); histone H3K23ac reader activity (ortholog); INVOLVED IN calcium ion homeostasis (ortholog); cellular response to estrogen stimulus (ortholog); negative regulation of cell population proliferat ion (ortholog); PARTICIPATES IN histone modification pathway; retinoic acid signaling pathway; ASSOCIATED WITH castration-resistant prostate carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (ortholog); euchromatin (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238374 | trim24 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626095093 | Trim24 | tripartite motif containing 24 | ENCODES a protein that exhibits chromatin binding (ortholog); estrogen response element binding (ortholog); histone H3K23ac reader activity (ortholog); INVOLVED IN calcium ion homeostasis (ortholog); cellular response to estrogen stimulus (ortholog); negative regulation of cell population proliferat ion (ortholog); PARTICIPATES IN histone modification pathway; retinoic acid signaling pathway; ASSOCIATED WITH castration-resistant prostate carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (ortholog); euchromatin (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14015706 | TRIM24 | tripartite motif containing 24 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); estrogen response element binding (inferred); INVOLVED IN calcium ion homeostasis (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of DNA-templated transcription (ort holog); PARTICIPATES IN histone modification pathway; retinoic acid signaling pathway; ASSOCIATED WITH castration-resistant prostate carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (inferred); euchromatin (inferred); nuclear lumen (inferred) | | | | Pig | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238375 | trim24.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259459 | trim24.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 18761297 | LOC103226979 | transcription intermediary factor 1-alpha | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); estrogen response element binding (inferred); INVOLVED IN calcium ion homeostasis (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of DNA-templated transcription (ort holog); PARTICIPATES IN histone modification pathway; retinoic acid signaling pathway; ASSOCIATED WITH castration-resistant prostate carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); hepatocellular carcinoma (ortholog); FOUND IN chromatin (inferred); cytoplasm (inferred); euchromatin (inferred) | | | | Green Monkey | 65 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |