Tmem67 Gene Search Result

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

Genes search result for All species
(View Results for all Objects and Ontologies)

14 records found for search term Tmem67

Refine Term:

Sort By:

Export

RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1316347	Tmem67	transmembrane protein 67	Predicted to enable filamin binding activity; misfolded protein binding activity; and unfolded protein binding activity. Involved in several processes, including epithelial tube branching involved in lung morphogenesis; negative regulation of centrosome duplication; and non-canonical Wnt signaling p ... (more) athway. Acts upstream of or within determination of left/right symmetry; heart development; and kidney development. Located in cytoplasmic vesicle membrane and endoplasmic reticulum membrane. Part of MKS complex. Is expressed in diencephalon; hindbrain lateral wall; metanephros; and organ of Corti. Used to study Joubert syndrome 6; Meckel syndrome; cystic kidney disease; and visceral heterotaxy. Human ortholog(s) of this gene implicated in several diseases, including Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis (multiple). Orthologous to human TMEM67 (transmembrane protein 67). [provided by Alliance of Genome Resources, Jul 2025]	4	12039355	12090020	Mouse	235	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1586167	Tmem67	transmembrane protein 67	ENCODES a protein that exhibits misfolded protein binding; filamin binding (ortholog); unfolded protein binding (ortholog); INVOLVED IN cilium assembly; head development; negative regulation of centrosome duplication; PARTICIPATES IN Wnt signaling, non-canonical pathway; ASSOCIATED WITH abnormal blo ... (more) od-cerebrospinal fluid barrier function; abnormal cerebrospinal fluid flow; abnormal ciliary body morphology; ASSOCIATED WITH autosomal recessive polycystic kidney disease; communicating hydrocephalus; hydrocephalus; FOUND IN axoneme; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A	5	30333793	30386702	Rat	221	symbol , PhenoGen	gene, protein-coding, VALIDATED [RefSeq]
1606753	TMEM67	transmembrane protein 67	The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this g ... (more) ene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008]	8	93754844	93832653	Human	1026	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
8761819	Tmem67	transmembrane protein 67	ENCODES a protein that exhibits filamin binding (ortholog); misfolded protein binding (ortholog); unfolded protein binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); cilium assembly (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN Wn ... (more) t signaling, non-canonical pathway; ASSOCIATED WITH atypical hemolytic-uremic syndrome (ortholog); autosomal recessive polycystic kidney disease (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN axoneme (ortholog); centrosome (ortholog); ciliary membrane (ortholog)	NW_004955417	10097488	10137959	Chinchilla	96	symbol	gene, protein-coding, MODEL [RefSeq]
11975770	TMEM67	transmembrane protein 67	ENCODES a protein that exhibits misfolded protein binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); determination of left/right symmetry (ortholog); epithelial tube branching involved in lung morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, non-canonic ... (more) al pathway; ASSOCIATED WITH atypical hemolytic-uremic syndrome (ortholog); autosomal recessive polycystic kidney disease (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN axoneme (ortholog)	8	90378623	90442904	Bonobo	91	symbol	gene, protein-coding, MODEL [RefSeq]
12231828	TMEM67	transmembrane protein 67	ENCODES a protein that exhibits misfolded protein binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); determination of left/right symmetry (ortholog); epithelial tube branching involved in lung morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, non-canonic ... (more) al pathway; ASSOCIATED WITH atypical hemolytic-uremic syndrome (ortholog); autosomal recessive polycystic kidney disease (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN axoneme (ortholog)	29	38655531	38715774	Dog	91	symbol	gene, protein-coding, MODEL [RefSeq]
12485604	Tmem67	transmembrane protein 67	ENCODES a protein that exhibits misfolded protein binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); determination of left/right symmetry (ortholog); epithelial tube branching involved in lung morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, non-canonic ... (more) al pathway; ASSOCIATED WITH atypical hemolytic-uremic syndrome (ortholog); autosomal recessive polycystic kidney disease (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN axoneme (ortholog)	NW_004936544	6887867	6931669	Squirrel	91	symbol	gene, protein-coding, MODEL [RefSeq]
14186306	TMEM67	transmembrane protein 67	ENCODES a protein that exhibits misfolded protein binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); determination of left/right symmetry (ortholog); epithelial tube branching involved in lung morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, non-canonic ... (more) al pathway; ASSOCIATED WITH atypical hemolytic-uremic syndrome (ortholog); autosomal recessive polycystic kidney disease (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN axoneme (ortholog)				Pig	91	symbol	gene, protein-coding, MODEL [RefSeq]
18921972	Tmem67	transmembrane protein 67	ENCODES a protein that exhibits filamin binding (ortholog); misfolded protein binding (ortholog); unfolded protein binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); determination of left/right symmetry (ortholog); epithelial tube branching involved in lung mor ... (more) phogenesis (ortholog); PARTICIPATES IN Wnt signaling, non-canonical pathway; ASSOCIATED WITH atypical hemolytic-uremic syndrome (ortholog); autosomal recessive polycystic kidney disease (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN axoneme (ortholog); centrosome (ortholog); ciliary membrane (ortholog)				Naked Mole-Rat	95	symbol	gene, protein-coding, MODEL [RefSeq]
625853683	Tmem67	transmembrane protein 67	ENCODES a protein that exhibits filamin binding (ortholog); misfolded protein binding (ortholog); unfolded protein binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); cilium assembly (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN Wn ... (more) t signaling, non-canonical pathway; ASSOCIATED WITH atypical hemolytic-uremic syndrome (ortholog); autosomal recessive polycystic kidney disease (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN axoneme (ortholog); centrosome (ortholog); ciliary membrane (ortholog)				Black Rat	88	symbol	gene, protein-coding, MODEL [RefSeq]
18478174	TMEM67	transmembrane protein 67	ENCODES a protein that exhibits misfolded protein binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); determination of left/right symmetry (ortholog); epithelial tube branching involved in lung morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, non-canonic ... (more) al pathway; ASSOCIATED WITH atypical hemolytic-uremic syndrome (ortholog); autosomal recessive polycystic kidney disease (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN axoneme (ortholog)				Green Monkey	91	symbol	gene, protein-coding, MODEL [RefSeq]
155259077	tmem67						Tropical Clawed Frog		symbol	gene, null
155232506	tmem67.S						African Clawed Frog		symbol	gene, null
14995943	Tmem67^wpk	transmembrane protein 67; wpk mutant	INVOLVED IN head development; ASSOCIATED WITH abnormal blood-cerebrospinal fluid barrier function; abnormal cerebrospinal fluid flow; abnormal ciliary body morphology; ASSOCIATED WITH autosomal recessive polycystic kidney disease; communicating hydrocephalus; hydrocephalus				Rat	33	symbol	gene, allele