| 1588633 | Tm4sf20 | transmembrane 4 L six family member 20 | INVOLVED IN negative regulation of proteolysis (ortholog); ASSOCIATED WITH Specific Language Impairment 5 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione | 9 | 91486847 | 91500745 | Rat | 60 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1605628 | TM4SF20 | transmembrane 4 L six family member 20 | The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high level s in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Knockout of the homologous gene in mouse results in a neurobehavioral phenotype with suggested enhanced motor coordination. A deletion mutation in the human gene is associated with specific language impairment-5. [provided by RefSeq, Jul 2016] | 2 | 227362038 | 227381647 | Human | 69 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1614373 | Tm4sf20 | transmembrane 4 L six family member 20 | Predicted to be involved in negative regulation of proteolysis. Predicted to be located in endoplasmic reticulum membrane; focal adhesion; and plasma membrane. Predicted to be active in membrane. Is expressed in alimentary system; central nervous system; lung; retina; and urethra. Human ortholog(s) of this gene implicated in specific language impairment. Orthologous to human TM4SF20 (transmembrane 4 L six family member 20). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 82734368 | 82746182 | Mouse | 68 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8936960 | Tm4sf20 | transmembrane 4 L six family member 20 | INVOLVED IN negative regulation of proteolysis (ortholog); ASSOCIATED WITH Specific Language Impairment 5 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); plasma membrane (ortholog) | NW_004955453 | 7201738 | 7219322 | Chinchilla | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12030862 | TM4SF20 | transmembrane 4 L six family member 20 | INVOLVED IN negative regulation of proteolysis (ortholog); ASSOCIATED WITH Specific Language Impairment 5 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); plasma membrane (ortholog) | 2B | 114606488 | 114623569 | Bonobo | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12290397 | TM4SF20 | transmembrane 4 L six family member 20 | INVOLVED IN negative regulation of proteolysis (inferred); ASSOCIATED WITH Specific Language Impairment 5 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred); plasma membrane (inferred) | 25 | 40148578 | 40159975 | Dog | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12509821 | Tm4sf20 | transmembrane 4 L six family member 20 | INVOLVED IN negative regulation of proteolysis (inferred); ASSOCIATED WITH Specific Language Impairment 5 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred); plasma membrane (inferred) | NW_004936525 | 8587236 | 8600780 | Squirrel | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233554 | tm4sf20 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18373776 | TM4SF20 | transmembrane 4 L six family member 20 | INVOLVED IN negative regulation of proteolysis (inferred); ASSOCIATED WITH Specific Language Impairment 5 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14016840 | TM4SF20 | transmembrane 4 L six family member 20 | INVOLVED IN negative regulation of proteolysis (inferred); ASSOCIATED WITH Specific Language Impairment 5 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred); plasma membrane (inferred) | | | | Pig | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625948380 | Tm4sf20 | transmembrane 4 L six family member 20 | INVOLVED IN negative regulation of proteolysis (ortholog); ASSOCIATED WITH Specific Language Impairment 5 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); plasma membrane (ortholog) | | | | Black Rat | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910699 | Tm4sf20 | transmembrane 4 L six family member 20 | INVOLVED IN negative regulation of proteolysis (inferred); ASSOCIATED WITH Specific Language Impairment 5 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239315 | tm4sf20.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155233555 | tm4sf20.S | | | | | | African Clawed Frog | | symbol | gene, null |