ENCODES a protein that exhibits histone acetyltransferase activity (ortholog); INVOLVED IN chromatin organization (ortholog); mitotic cell cycle (ortholog); regulation of cell cycle (ortholog); PARTICIPATES IN RNA polymerase II transcription initiation pathway; FOUND IN ATAC complex (ortholog); mito
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to ac
etylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]
Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Acts upstream of or within several process
es, including chromatin organization; regulation of protein modification process; and regulation of protein stability. Located in mitotic spindle and nucleus. Part of ATAC complex. Orthologous to human TADA2A (transcriptional adaptor 2A). [provided by Alliance of Genome Resources, Jul 2025]
ENCODES a protein that exhibits histone acetyltransferase activity (ortholog); INVOLVED IN chromatin organization (ortholog); mitotic cell cycle (ortholog); regulation of DNA-templated transcription (ortholog); PARTICIPATES IN RNA polymerase II transcription initiation pathway; FOUND IN SAGA complex