| 619716 | Sv2b | synaptic vesicle glycoprotein 2b | ENCODES a protein that exhibits transmembrane transporter activity (inferred); INVOLVED IN regulation of presynaptic cytosolic calcium ion concentration (ortholog); regulation of synaptic vesicle exocytosis (ortholog); PARTICIPATES IN cell-extracellular matrix signaling pathway; ASSOCIATED WITH kidn ey disease (ortholog); prostate cancer (ortholog); spinal muscular atrophy (ortholog); FOUND IN glutamatergic synapse; synaptic vesicle; synaptic vesicle membrane; INTERACTS WITH 17alpha-ethynylestradiol; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil | 1 | 138388268 | 138562635 | Rat | 101 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1332062 | Sv2b | synaptic vesicle glycoprotein 2b | Predicted to enable transmembrane transporter activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in synaptic vesicle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SV2B (synaptic vesicle glycoprotein 2B). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 74764642 | 74959143 | Mouse | 108 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1343420 | SV2B | synaptic vesicle glycoprotein 2B | This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016] | 15 | 91099588 | 91302565 | Human | 98 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8840078 | Sv2b | synaptic vesicle glycoprotein 2B | INVOLVED IN regulation of presynaptic cytosolic calcium ion concentration (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH kidney disease (ortholog); prostate cancer (ortholog); spinal muscular atrophy (ortholog); FOUND IN glutamatergic synapse (ortholog); synaptic v esicle (ortholog); synaptic vesicle membrane (ortholog) | NW_004955416 | 19456414 | 19650782 | Chinchilla | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11951946 | SV2B | synaptic vesicle glycoprotein 2B | ENCODES a protein that exhibits transmembrane transporter activity (inferred); INVOLVED IN regulation of presynaptic cytosolic calcium ion concentration (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH kidney disease (ortholog); prostate cancer (ortholog); spinal mus cular atrophy (ortholog); FOUND IN glutamatergic synapse (ortholog); synaptic vesicle (ortholog); synaptic vesicle membrane (ortholog) | 15 | 69793642 | 69989339 | Bonobo | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12330202 | SV2B | synaptic vesicle glycoprotein 2B | ENCODES a protein that exhibits transmembrane transporter activity (inferred); INVOLVED IN chemical synaptic transmission (inferred); neurotransmitter transport (inferred); regulation of presynaptic cytosolic calcium ion concentration (inferred); ASSOCIATED WITH kidney disease (ortholog); prostate c ancer (ortholog); spinal muscular atrophy (ortholog); FOUND IN glutamatergic synapse (ortholog); synaptic vesicle (ortholog) | 3 | 48694905 | 48870157 | Dog | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12463705 | Sv2b | synaptic vesicle glycoprotein 2B | ENCODES a protein that exhibits transmembrane transporter activity (inferred); INVOLVED IN chemical synaptic transmission (inferred); neurotransmitter transport (inferred); regulation of presynaptic cytosolic calcium ion concentration (inferred); ASSOCIATED WITH kidney disease (ortholog); prostate c ancer (ortholog); spinal muscular atrophy (ortholog); FOUND IN glutamatergic synapse (ortholog); synaptic vesicle (ortholog); synaptic vesicle membrane (ortholog) | NW_004936483 | 11377375 | 11450830 | Squirrel | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625927805 | Sv2b | synaptic vesicle glycoprotein 2B | INVOLVED IN regulation of presynaptic cytosolic calcium ion concentration (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH kidney disease (ortholog); prostate cancer (ortholog); spinal muscular atrophy (ortholog); FOUND IN glutamatergic synapse (ortholog); synaptic v esicle (ortholog); synaptic vesicle membrane (ortholog) | | | | Black Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13966149 | SV2B | synaptic vesicle glycoprotein 2B | ENCODES a protein that exhibits transmembrane transporter activity (inferred); INVOLVED IN chemical synaptic transmission (inferred); neurotransmitter transport (inferred); regulation of presynaptic cytosolic calcium ion concentration (inferred); ASSOCIATED WITH kidney disease (ortholog); prostate c ancer (ortholog); spinal muscular atrophy (ortholog); FOUND IN glutamatergic synapse (ortholog); synaptic vesicle (ortholog) | | | | Pig | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18906888 | Sv2b | synaptic vesicle glycoprotein 2B | ENCODES a protein that exhibits transmembrane transporter activity (inferred); INVOLVED IN regulation of presynaptic cytosolic calcium ion concentration (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH kidney disease (ortholog); prostate cancer (ortholog); spinal mus cular atrophy (ortholog); FOUND IN glutamatergic synapse (ortholog); synaptic vesicle (ortholog); synaptic vesicle membrane (ortholog) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249342 | sv2b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18339072 | SV2B | synaptic vesicle glycoprotein 2B | ENCODES a protein that exhibits transmembrane transporter activity (inferred); INVOLVED IN regulation of presynaptic cytosolic calcium ion concentration (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH kidney disease (ortholog); prostate cancer (ortholog); spinal mus cular atrophy (ortholog); FOUND IN glutamatergic synapse (ortholog); synaptic vesicle (ortholog); synaptic vesicle membrane (ortholog) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405857279 | sv2b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626180688 | sv2b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864590 | sv2b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857480 | sv2b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863440 | sv2b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864750 | sv2b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856423 | sv2b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857294 | sv2b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359482 | sv2b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359548 | sv2b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359332 | sv2b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860920 | sv2b.S | | | | | | African Clawed Frog | | symbol | gene, null |