| 1318473 | SPDEF | SAM pointed domain containing ETS transcription factor | The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] | 6 | 34537802 | 34556329 | Human | 101 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1318474 | Spdef | SAM pointed domain containing ets transcription factor | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including epithelial cell differentiation; positive regulation of cell fate commitment; and regulation o f transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SPDEF (SAM pointed domain containing ETS transcription factor). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 27933416 | 27949977 | Mouse | 114 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1594842 | Spdef | SAM pointed domain containing ets transcription factor | ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN intestinal epithelial cell development (ortholog); lung goblet cell differentiation (ortholog); negative regulation of cell fate commitment (ortholog); ASSO CIATED WITH ovarian cancer (ortholog); Ovarian Neoplasms (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A | 20 | 5773236 | 5787685 | Rat | 99 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8765153 | Spdef | SAM pointed domain containing ETS transcription factor | ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN intestinal epithelial cell development (ortholog); lung goblet cell differentiation (ortholog); negative regulation of cell fate commitment (ortholog); ASSO CIATED WITH ovarian cancer (ortholog); Ovarian Neoplasms (ortholog); FOUND IN nucleus (ortholog) | NW_004955437 | 2667499 | 2679940 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12154878 | SPDEF | SAM pointed domain containing ETS transcription factor | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); sequence-specific DNA binding (inferred); INVOLVED IN intestinal epithelial cell development (ortholog); lung goblet cell differentiation (ortholog); negative regulation of cell fate commitm ent (ortholog); ASSOCIATED WITH ovarian cancer (ortholog); Ovarian Neoplasms (ortholog); FOUND IN nucleus (inferred) | 12 | 3814806 | 3831724 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12605949 | Spdef | SAM pointed domain containing ETS transcription factor | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN intestinal epithelial cell development (ortholog); lung goblet cell differentiation (ortholog); negative regulation of cell fate commitment (ortholog); ASSOCIATED WITH ovarian cancer (ortholog); Ovarian Neoplasms (ortholog); FOUND IN nucleus (inferred) | NW_004936476 | 24563591 | 24571739 | Squirrel | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18713490 | SPDEF | SAM pointed domain containing ETS transcription factor | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN intestinal epithelial cell development (ortholog); lung goblet cell differentiation (ortholog); negative regulation of cell fate commitment (ortholog); ASSOCIATED WITH ovarian cancer (ortholog); Ovarian Neoplasms (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626064410 | Spdef | SAM pointed domain containing ETS transcription factor | ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN intestinal epithelial cell development (ortholog); lung goblet cell differentiation (ortholog); negative regulation of cell fate commitment (ortholog); ASSO CIATED WITH ovarian cancer (ortholog); Ovarian Neoplasms (ortholog); FOUND IN nucleus (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931622 | Spdef | SAM pointed domain containing ETS transcription factor | ENCODES a protein that exhibits sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN intestinal epithelial cell development (ortholog); lung goblet cell differentiation (ortholog); negative regulation of cell fate commitment (ortholog); ASSOCIATED WITH ovarian cancer (ortholog); Ova rian Neoplasms (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14280500 | SPDEF | SAM pointed domain containing ETS transcription factor | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); sequence-specific DNA binding (inferred); INVOLVED IN intestinal epithelial cell development (ortholog); lung goblet cell differentiation (ortholog); negative regulation of cell fate commitm ent (ortholog); ASSOCIATED WITH ovarian cancer (ortholog); Ovarian Neoplasms (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH Estradiol 17beta-cyclopentylpropionate | | | | Pig | 32 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155250289 | spdef | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 329888069 | SPDEF | SAM pointed domain containing ETS transcription factor | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN intestinal epithelial cell development (ortholog); lung goblet cell differentiation (ortholog); negative regulation of cell fate commitment (ortholog); ASSOCIATED WITH ovarian cancer (ortholog); Ovarian Neoplasms (ortholog); FOUND IN nucleus (inferred) | | | | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234631 | spdef.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 11914281 | ILRUN | inflammation and lipid regulator with UBA-like and NBR1-like domains | ENCODES a protein that exhibits ubiquitin binding (inferred); INVOLVED IN immune system process (inferred); innate immune response (inferred); macroautophagy (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred) | 6 | 34102610 | 34140800 | Bonobo | 16 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |