| 1311316 | Sike1 | suppressor of IKBKE 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-macromolecule adaptor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of hippo signaling (ortholog); FOUND IN FAR/SIN/STRIPAK complex (ortholog); INTERACTS WITH bisphenol A; cocaine; deca bromodiphenyl ether | 2 | 193206490 | 193214321 | Rat | 51 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1332556 | Sike1 | suppressor of IKBKE 1 | Predicted to enable protein kinase binding activity; protein-macromolecule adaptor activity; and small GTPase binding activity. Predicted to be involved in negative regulation of hippo signaling. Predicted to be located in cytoplasm. Predicted to be part of FAR/SIN/STRIPAK complex. Is expressed in h eart ventricle and nervous system. Orthologous to human SIKE1 (suppressor of IKBKE 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 102903056 | 102911230 | Mouse | 72 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1602207 | SIKE1 | suppressor of IKBKE 1 | SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008] | 1 | 114769479 | 114780685 | Human | 54 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8700722 | Sike1 | suppressor of IKBKE 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-macromolecule adaptor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of hippo signaling (ortholog); FOUND IN FAR/SIN/STRIPAK complex (ortholog) | NW_004955435 | 18066428 | 18076422 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12042472 | SIKE1 | suppressor of IKBKE 1 | ENCODES a protein that exhibits protein kinase binding (inferred); protein-macromolecule adaptor activity (inferred); small GTPase binding (inferred); INVOLVED IN negative regulation of hippo signaling (inferred); FOUND IN FAR/SIN/STRIPAK complex (inferred) | 1 | 87773469 | 87785099 | Bonobo | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12372638 | SIKE1 | suppressor of IKBKE 1 | ENCODES a protein that exhibits protein kinase binding (inferred); protein-macromolecule adaptor activity (inferred); small GTPase binding (inferred); INVOLVED IN negative regulation of hippo signaling (inferred); FOUND IN FAR/SIN/STRIPAK complex (inferred) | 17 | 52468471 | 52475883 | Dog | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12629911 | Sike1 | suppressor of IKBKE 1 | ENCODES a protein that exhibits protein kinase binding (inferred); protein-macromolecule adaptor activity (inferred); small GTPase binding (inferred); INVOLVED IN negative regulation of hippo signaling (inferred); FOUND IN FAR/SIN/STRIPAK complex (inferred) | NW_004936627 | 138163 | 144469 | Squirrel | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238686 | sike1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18907292 | Sike1 | suppressor of IKBKE 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-macromolecule adaptor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of hippo signaling (ortholog); FOUND IN FAR/SIN/STRIPAK complex (ortholog) | | | | Naked Mole-Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18531490 | SIKE1 | suppressor of IKBKE 1 | ENCODES a protein that exhibits protein kinase binding (inferred); protein-macromolecule adaptor activity (inferred); small GTPase binding (inferred); INVOLVED IN negative regulation of hippo signaling (inferred); FOUND IN FAR/SIN/STRIPAK complex (inferred) | | | | Green Monkey | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13856758 | SIKE1 | suppressor of IKBKE 1 | ENCODES a protein that exhibits protein kinase binding (inferred); protein-macromolecule adaptor activity (inferred); small GTPase binding (inferred); INVOLVED IN negative regulation of hippo signaling (inferred); FOUND IN FAR/SIN/STRIPAK complex (inferred) | | | | Pig | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625959180 | Sike1 | suppressor of IKBKE 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-macromolecule adaptor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of hippo signaling (ortholog); FOUND IN FAR/SIN/STRIPAK complex (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236235 | sike1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241240 | sike1.S | | | | | | African Clawed Frog | | symbol | gene, null |