ENCODES a protein that exhibits GTPase activator activity (inferred); phosphatidylinositol binding (inferred); phosphatidylinositol phosphate binding (inferred); INVOLVED IN cerebellum development; positive regulation of axon extension; positive regulation of neuron migration; ASSOCIATED WITH autism
Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of axon extension; positive regulation of neuron migration; and small GTPase-mediated signal transduction. Predicted to act upstream of or within Rho protein signal transduction. Located in actin cytoskele
ton; cell cortex; and postsynaptic density. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study autism spectrum disorder. Orthologous to human ARHGAP32 (Rho GTPase activating protein 32). [provided by Alliance of Genome Resources, Jul 2025]
RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]