| 620476 | Rasgrp4 | RAS guanyl releasing protein 4 | ENCODES a protein that exhibits diacylglycerol binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN antibacterial innate immune response (ortholog); phospholipase C-activating G protein-coupled receptor signaling pathway (ortholog); positive regulation of natural ki ller cell mediated immunity (ortholog); PARTICIPATES IN mitogen activated protein kinase signaling pathway; FOUND IN cytoplasmic side of plasma membrane (ortholog); cytosol (ortholog); membrane (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; bisphenol A | 1 | 93560513 | 93580321 | Rat | 75 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733193 | RASGRP4 | RAS guanyl releasing protein 4 | The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a c ation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009] | 19 | 38409058 | 38426219 | Human | 75 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 733194 | Rasgrp4 | RAS guanyl releasing protein 4 | Enables diacylglycerol binding activity. Involved in antibacterial innate immune response; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of natural killer cell mediated immunity. Located in cytoplasmic side of plasma membrane. Is expressed in severa l structures, including genitourinary system; liver; peritoneal cavity; spleen; and tongue. Orthologous to human RASGRP4 (RAS guanyl releasing protein 4). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 28834358 | 28853386 | Mouse | 80 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8816594 | Rasgrp4 | RAS guanyl releasing protein 4 | ENCODES a protein that exhibits diacylglycerol binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN antibacterial innate immune response (ortholog); phospholipase C-activating G protein-coupled receptor signaling pathway (ortholog); positive regulation of natural ki ller cell mediated immunity (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); cytosol (ortholog); membrane (ortholog) | NW_004955468 | 1007082 | 1020744 | Chinchilla | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11960206 | RASGRP4 | RAS guanyl releasing protein 4 | ENCODES a protein that exhibits calcium ion binding (inferred); diacylglycerol binding (inferred); GTPase regulator activity (inferred); INVOLVED IN antibacterial innate immune response (inferred); cell differentiation (inferred); phospholipase C-activating G protein-coupled receptor signaling pathw ay (inferred); FOUND IN cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred); cytosol (inferred) | 19 | 35503314 | 35520787 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12320533 | RASGRP4 | RAS guanyl releasing protein 4 | ENCODES a protein that exhibits calcium ion binding (inferred); diacylglycerol binding (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN antibacterial innate immune response (inferred); cell differentiation (inferred); phospholipase C-activating G protein-coupled recepto r signaling pathway (inferred); FOUND IN cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred); cytosol (inferred) | 1 | 114584535 | 114598870 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12572344 | Rasgrp4 | RAS guanyl releasing protein 4 | ENCODES a protein that exhibits calcium ion binding (inferred); diacylglycerol binding (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN antibacterial innate immune response (inferred); cell differentiation (inferred); phospholipase C-activating G protein-coupled recepto r signaling pathway (inferred); FOUND IN cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred); cytosol (inferred) | NW_004936801 | 1166676 | 1180508 | Squirrel | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14142406 | RASGRP4 | RAS guanyl releasing protein 4 | ENCODES a protein that exhibits diacylglycerol binding (inferred); guanyl-nucleotide exchange factor activity (inferred); lipid binding (inferred); INVOLVED IN antibacterial innate immune response (inferred); cell differentiation (inferred); phospholipase C-activating G protein-coupled receptor sign aling pathway (inferred); FOUND IN cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred); cytosol (inferred) | | | | Pig | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083415 | rasgrp4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18921882 | Rasgrp4 | RAS guanyl releasing protein 4 | ENCODES a protein that exhibits diacylglycerol binding (ortholog); INVOLVED IN antibacterial innate immune response (ortholog); phospholipase C-activating G protein-coupled receptor signaling pathway (ortholog); positive regulation of natural killer cell mediated immunity (ortholog); FOUND IN cytopl asmic side of plasma membrane (ortholog); cytosol (ortholog); membrane (ortholog) | | | | Naked Mole-Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18487977 | RASGRP4 | RAS guanyl releasing protein 4 | ENCODES a protein that exhibits calcium ion binding (inferred); diacylglycerol binding (inferred); GTPase regulator activity (inferred); INVOLVED IN antibacterial innate immune response (inferred); cell differentiation (inferred); phospholipase C-activating G protein-coupled receptor signaling pathw ay (inferred); FOUND IN cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred); cytosol (inferred) | | | | Green Monkey | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626012839 | Rasgrp4 | RAS guanyl releasing protein 4 | ENCODES a protein that exhibits diacylglycerol binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN antibacterial innate immune response (ortholog); phospholipase C-activating G protein-coupled receptor signaling pathway (ortholog); positive regulation of natural ki ller cell mediated immunity (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); cytosol (ortholog); membrane (ortholog) | | | | Black Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285538380 | rasgrp4.L | | | | | | African Clawed Frog | | symbol | gene, null |
