| 1309908 | Rap1gap | Rap1 GTPase-activating protein | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein homodimerization activity (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to glial cell derived neurotrophic factor; negative regulation of neuron differentiation; negative regulation of thyroid gland epithelial cell proliferation; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); bipolar disorder (ortholog); Disease Progression (ortholog); FOUND IN axon; dendrite; early endosome; INTERACTS WITH 4,4'-sulfonyldiphenol; acetamide; aflatoxin B1 | 5 | 155157511 | 155222622 | Rat | 165 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1320507 | RAP1GAP | RAP1 GTPase activating protein | This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP span>, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011] | 1 | 21596221 | 21669357 | Human | 177 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1551379 | Rap1gap | Rap1 GTPase-activating protein | Predicted to enable GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Acts upstream of or within positive regulation of cell-cell adhesion and positive regulation of phagocytosis. Predicted to be located in several cellular components, including dendrit e; early endosome; and neuronal cell body. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including metanephros; nervous system; pancreas; sensory organ; and skeleton. Orthologous to human RAP1GAP (RAP1 GTPase activating protein). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 137391549 | 137457172 | Mouse | 177 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 9025581 | Rap1gap | RAP1 GTPase activating protein | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein homodimerization activity (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to glial cell derived neurotrophic factor (ortholog); negative regulation of microvillus assembly (ortholog); negative re gulation of neuron differentiation (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); bipolar disorder (ortholog); Disease Progression (ortholog); FOUND IN axon (ortholog); cytosol (ortholog); dendrite (ortholog) | NW_004955452 | 1886557 | 1950942 | Chinchilla | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11862255 | RAP1GAP | RAP1 GTPase activating protein | ENCODES a protein that exhibits GTPase activator activity (inferred); GTPase regulator activity (inferred); protein homodimerization activity (inferred); INVOLVED IN cellular response to glial cell derived neurotrophic factor (ortholog); negative regulation of neuron differentiation (ortholog); nega tive regulation of thyroid gland epithelial cell proliferation (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); bipolar disorder (ortholog); Disease Progression (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); early endosome (ortholog) | 1 | 20790076 | 20860511 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12406696 | RAP1GAP | RAP1 GTPase activating protein | ENCODES a protein that exhibits GTPase activator activity (inferred); GTPase regulator activity (inferred); protein homodimerization activity (inferred); INVOLVED IN cellular response to glial cell derived neurotrophic factor (ortholog); negative regulation of neuron differentiation (ortholog); nega tive regulation of thyroid gland epithelial cell proliferation (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); bipolar disorder (ortholog); Disease Progression (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); early endosome (ortholog) | 2 | 77509592 | 77554620 | Dog | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12608043 | Rap1gap | RAP1 GTPase activating protein | ENCODES a protein that exhibits GTPase activator activity (inferred); GTPase regulator activity (inferred); protein homodimerization activity (inferred); INVOLVED IN cellular response to glial cell derived neurotrophic factor (ortholog); negative regulation of neuron differentiation (ortholog); nega tive regulation of thyroid gland epithelial cell proliferation (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); bipolar disorder (ortholog); Disease Progression (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); early endosome (ortholog) | NW_004936474 | 7242528 | 7284342 | Squirrel | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13971370 | RAP1GAP | RAP1 GTPase activating protein | ENCODES a protein that exhibits GTPase activator activity (inferred); GTPase regulator activity (inferred); protein homodimerization activity (inferred); INVOLVED IN cellular response to glial cell derived neurotrophic factor (ortholog); negative regulation of neuron differentiation (ortholog); nega tive regulation of thyroid gland epithelial cell proliferation (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); bipolar disorder (ortholog); Disease Progression (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); early endosome (ortholog) | | | | Pig | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18635966 | RAP1GAP | RAP1 GTPase activating protein | ENCODES a protein that exhibits GTPase activator activity (inferred); GTPase regulator activity (inferred); protein homodimerization activity (inferred); INVOLVED IN cellular response to glial cell derived neurotrophic factor (ortholog); negative regulation of neuron differentiation (ortholog); nega tive regulation of thyroid gland epithelial cell proliferation (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); bipolar disorder (ortholog); Disease Progression (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); early endosome (ortholog) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922823 | Rap1gap | RAP1 GTPase activating protein | ENCODES a protein that exhibits protein homodimerization activity (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to glial cell derived neurotrophic factor (ortholog); negative regulation of microvillus assembly (ortholog); negative regulation of neuron differentiation (or tholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); bipolar disorder (ortholog); Disease Progression (ortholog); FOUND IN axon (ortholog); cytosol (ortholog); dendrite (ortholog) | | | | Naked Mole-Rat | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285760917 | rap1gap | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626120280 | Rap1gap | RAP1 GTPase activating protein | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein homodimerization activity (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to glial cell derived neurotrophic factor (ortholog); negative regulation of microvillus assembly (ortholog); negative re gulation of neuron differentiation (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); bipolar disorder (ortholog); Disease Progression (ortholog); FOUND IN axon (ortholog); cytosol (ortholog); dendrite (ortholog) | | | | Black Rat | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285760208 | rap1gap.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 287274624 | rap1gap.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1304590 | Rap1gap2 | RAP1 GTPase activating protein 2 | ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN negative regulation of neuron projection development (ortholog); regulation of cell size (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodi oxine; acetamide; alpha-Zearalanol | 10 | 59753822 | 59970946 | Rat | 122 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1312118 | Rap1gap2 | RAP1 GTPase activating protein 2 | Enables GTPase activator activity. Acts upstream of or within negative regulation of neuron projection development. Located in cytoplasm and neuron projection. Is expressed in olfactory epithelium; pancreas; and telencephalon. Orthologous to human RAP1GAP2 (RAP1 GTPase activating protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 74274182 | 74501796 | Mouse | 131 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1346377 | RAP1GAP2 | RAP1 GTPase activating protein 2 | This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] | 17 | 2755645 | 3037741 | Human | 124 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9006776 | Rap1gap2 | RAP1 GTPase activating protein 2 | ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN negative regulation of neuron projection development (ortholog); regulation of cell size (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955481 | 296411 | 537490 | Chinchilla | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11964986 | RAP1GAP2 | RAP1 GTPase activating protein 2 | ENCODES a protein that exhibits GTPase activator activity (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); FOUND IN neuron projection (ortholog) | 17 | 2742454 | 3031659 | Bonobo | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12393528 | RAP1GAP2 | RAP1 GTPase activating protein 2 | ENCODES a protein that exhibits GTPase activator activity (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); FOUND IN cytoplasm (ortholog); neuron projection (ortholog) | 9 | 46815587 | 47015038 | Dog | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12640851 | Rap1gap2 | RAP1 GTPase activating protein 2 | ENCODES a protein that exhibits GTPase activator activity (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); FOUND IN neuron projection (ortholog) | NW_004936538 | 8755379 | 8977432 | Squirrel | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13859605 | RAP1GAP2 | RAP1 GTPase activating protein 2 | ENCODES a protein that exhibits GTPase activator activity (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); FOUND IN cytoplasm (ortholog); neuron projection (ortholog) | | | | Pig | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18369750 | RAP1GAP2 | RAP1 GTPase activating protein 2 | ENCODES a protein that exhibits GTPase activator activity (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); FOUND IN neuron projection (ortholog) | | | | Green Monkey | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917180 | Rap1gap2 | RAP1 GTPase activating protein 2 | ENCODES a protein that exhibits GTPase activator activity (inferred); INVOLVED IN negative regulation of neuron projection development (ortholog); regulation of cell size (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); neuron projection (ortholog) | | | | Naked Mole-Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256487 | rap1gap2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625856064 | Rap1gap2 | RAP1 GTPase activating protein 2 | ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN negative regulation of neuron projection development (ortholog); regulation of cell size (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1609307 | Rap1gapos | RAP1 GTPase activating protein, opposite strand | | 4 | 137424285 | 137433917 | Mouse | 3 | symbol , PhenoGen | gene, ncrna, VALIDATED [RefSeq] |
| 155260169 | rap1gap2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236509 | rap1gap2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16563642 | RAP1GAP2-AS1 | RAP1GAP2 antisense RNA 1 | | 17 | 2962247 | 2965895 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |