| 620040 | Prdx3 | peroxiredoxin 3 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); identical protein binding (ortholog); protein kinase binding (ortholog); INVOLVED IN negative regulation of neuron apoptotic process; cellular response to oxidative stress (orthol og); cellular response to reactive oxygen species (ortholog); ASSOCIATED WITH glucose intolerance; Insulin Resistance; autosomal recessive cerebellar ataxia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); early endosome (ortholog); INTERACTS WITH 1,1'-azobis(N,N-dimethylformamide); 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 269987691 | 270000111 | Rat | 335 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732403 | Prdx3 | peroxiredoxin 3 | Enables identical protein binding activity. Acts upstream of or within several processes, including maternal placenta development; myeloid cell differentiation; and response to lipopolysaccharide. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary sy stem; eye; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 32. Orthologous to human PRDX3 (peroxiredoxin 3). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 60852504 | 60862976 | Mouse | 370 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1349610 | PRDX3 | peroxiredoxin 3 | This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are high ly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014] | 10 | 119167720 | 119178812 | Human | 354 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8749579 | Prdx3 | peroxiredoxin 3 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); identical protein binding (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to oxidative stress (ortholog); cellular response to reactive oxygen species (ortholog); hydrogen peroxide catabolic process (ortholog); ASSOCIATED WITH autosomal recessive cerebellar ataxia (ortholog); autosomal recessive spinocerebellar ataxia 32 (ortholog); CORNEAL DYSTROPHY, PUNCTIFORM AND POLYCHROMATIC PRE-DESCEMET (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); early endosome (ortholog) | NW_004955431 | 23640775 | 23651738 | Chinchilla | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11782206 | PRDX3 | peroxiredoxin 3 | ENCODES a protein that exhibits antioxidant activity (inferred); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (inferred); identical protein binding (inferred); INVOLVED IN hydrogen peroxide catabolic process (ortholog); maternal placenta development (ortholog); myeloi d cell differentiation (ortholog); ASSOCIATED WITH autosomal recessive cerebellar ataxia (ortholog); autosomal recessive spinocerebellar ataxia 32 (ortholog); CORNEAL DYSTROPHY, PUNCTIFORM AND POLYCHROMATIC PRE-DESCEMET (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); early endosome (inferred) | 10 | 115738346 | 115749482 | Bonobo | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12248454 | PRDX3 | peroxiredoxin 3 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); identical protein binding (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to oxidative stress (ortholog); cellular response to reactive oxygen species (ortholog); hydrogen peroxide catabolic process (ortholog); ASSOCIATED WITH autosomal recessive cerebellar ataxia (ortholog); autosomal recessive spinocerebellar ataxia 32 (ortholog); CORNEAL DYSTROPHY, PUNCTIFORM AND POLYCHROMATIC PRE-DESCEMET (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); early endosome (ortholog) | 28 | 29395593 | 29403745 | Dog | 61 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12520608 | Prdx3 | peroxiredoxin 3 | ENCODES a protein that exhibits antioxidant activity (inferred); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (inferred); identical protein binding (inferred); INVOLVED IN hydrogen peroxide catabolic process (ortholog); maternal placenta development (ortholog); myeloi d cell differentiation (ortholog); ASSOCIATED WITH autosomal recessive cerebellar ataxia (ortholog); autosomal recessive spinocerebellar ataxia 32 (ortholog); CORNEAL DYSTROPHY, PUNCTIFORM AND POLYCHROMATIC PRE-DESCEMET (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); early endosome (inferred) | NW_004936486 | 8597479 | 8606727 | Squirrel | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625964889 | Prdx3 | peroxiredoxin 3 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); identical protein binding (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to oxidative stress (ortholog); cellular response to reactive oxygen species (ortholog); hydrogen peroxide catabolic process (ortholog); ASSOCIATED WITH autosomal recessive cerebellar ataxia (ortholog); autosomal recessive spinocerebellar ataxia 32 (ortholog); CORNEAL DYSTROPHY, PUNCTIFORM AND POLYCHROMATIC PRE-DESCEMET (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); early endosome (ortholog) | | | | Black Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18474105 | PRDX3 | peroxiredoxin 3 | ENCODES a protein that exhibits antioxidant activity (inferred); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (inferred); identical protein binding (inferred); INVOLVED IN hydrogen peroxide catabolic process (ortholog); maternal placenta development (ortholog); myeloi d cell differentiation (ortholog); ASSOCIATED WITH autosomal recessive cerebellar ataxia (ortholog); autosomal recessive spinocerebellar ataxia 32 (ortholog); CORNEAL DYSTROPHY, PUNCTIFORM AND POLYCHROMATIC PRE-DESCEMET (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); early endosome (inferred) | | | | Green Monkey | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911389 | Prdx3 | peroxiredoxin 3 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); identical protein binding (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to oxidative stress (ortholog); cellular response to reactive oxygen species (ortholog); hydrogen peroxide catabolic process (ortholog); ASSOCIATED WITH autosomal recessive cerebellar ataxia (ortholog); autosomal recessive spinocerebellar ataxia 32 (ortholog); CORNEAL DYSTROPHY, PUNCTIFORM AND POLYCHROMATIC PRE-DESCEMET (ortholog); FOUND IN cytoplasm (ortholog); early endosome (ortholog); protein-containing complex (ortholog) | | | | Naked Mole-Rat | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248421 | prdx3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14265502 | PRDX3 | peroxiredoxin 3 | ENCODES a protein that exhibits antioxidant activity (inferred); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (inferred); identical protein binding (inferred); INVOLVED IN hydrogen peroxide catabolic process (ortholog); maternal placenta development (ortholog); myeloi d cell differentiation (ortholog); ASSOCIATED WITH autosomal recessive cerebellar ataxia (ortholog); autosomal recessive spinocerebellar ataxia 32 (ortholog); CORNEAL DYSTROPHY, PUNCTIFORM AND POLYCHROMATIC PRE-DESCEMET (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); early endosome (inferred) | | | | Pig | 62 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155235112 | prdx3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249120 | prdx3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 7716912 | Prdx3-ps1 | peroxiredoxin 3, pseudogene 1 | | 1 | 115911399 | 115912298 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16559092 | AC026427.2 | peroxiredoxin 3 (PRDX3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16565624 | AC105129.3 | peroxiredoxin 3 (PRDX3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 4889295 | PRDX3P1 | peroxiredoxin 3 pseudogene 1 | | 22 | 38722544 | 38723522 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4889391 | PRDX3P2 | peroxiredoxin 3 pseudogene 2 | INTERACTS WITH aristolochic acid A | 1 | 28526358 | 28527238 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4889363 | PRDX3P3 | peroxiredoxin 3 pseudogene 3 | | 13 | 38617422 | 38617997 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7175196 | PRDX3P4 | peroxiredoxin 3 pseudogene 4 | | 3 | 64174378 | 64175347 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
