| 708460 | Ppp6c | protein phosphatase 6, catalytic subunit | ENCODES a protein that exhibits protein serine/threonine phosphatase activity; INVOLVED IN protein dephosphorylation; negative regulation of cGAS/STING signaling pathway (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog) ; melanoma (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione; ammonium chloride | 3 | 43339521 | 43371807 | Rat | 72 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734407 | PPP6C | protein phosphatase 6 catalytic subunit | This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008] | 9 | 125146573 | 125189803 | Human | 85 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 734408 | Ppp6c | protein phosphatase 6, catalytic subunit | Enables protein serine/threonine phosphatase activity. Predicted to be involved in G1/S transition of mitotic cell cycle and negative regulation of cGAS/STING signaling pathway. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytosol. Predicted to be acti ve in cytoplasm. Is expressed in central nervous system; pancreas epithelium; and retina. Orthologous to human PPP6C (protein phosphatase 6 catalytic subunit). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 39084381 | 39116361 | Mouse | 99 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8897290 | Ppp6c | protein phosphatase 6 catalytic subunit | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN negative regulation of cGAS/STING signaling pathway (ortholog); protein dephosphorylation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH basal cel l carcinoma (ortholog); melanoma (ortholog); FOUND IN cytosol (ortholog) | NW_004955419 | 3096882 | 3133590 | Chinchilla | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12035057 | PPP6C | protein phosphatase 6 catalytic subunit | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); melanoma (ortholog); FOUND IN cytosol (i nferred) | 9 | 96267918 | 96311159 | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12074503 | PPP6C | protein phosphatase 6 catalytic subunit | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN negative regulation of cGAS/STING signaling pathway (ortholog); protein dephosphorylation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH basal cel l carcinoma (ortholog); melanoma (ortholog); FOUND IN cytosol (ortholog) | 9 | 57884035 | 57921080 | Dog | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12609414 | Ppp6c | protein phosphatase 6 catalytic subunit | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); melanoma (ortholog); FOUND IN cytosol (i nferred) | NW_004936487 | 13284652 | 13320936 | Squirrel | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908698 | Ppp6c | protein phosphatase 6 catalytic subunit | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN negative regulation of cGAS/STING signaling pathway (ortholog); protein dephosphorylation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH basal cel l carcinoma (ortholog); melanoma (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234939 | ppp6c | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626093331 | Ppp6c | protein phosphatase 6 catalytic subunit | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN negative regulation of cGAS/STING signaling pathway (ortholog); protein dephosphorylation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH basal cel l carcinoma (ortholog); melanoma (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13995082 | PPP6C | protein phosphatase 6 catalytic subunit | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); melanoma (ortholog); FOUND IN cytosol (i nferred) | | | | Pig | 30 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18634562 | PPP6C | protein phosphatase 6 catalytic subunit | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); melanoma (ortholog); FOUND IN cytosol (i nferred) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258028 | ppp6c.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2321912 | Ppp6c-ps1 | protein phosphatase 6, catalytic subunit, pseudogene 1 | | 4 | 91300524 | 91327307 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16556806 | AL118496.1 | pseudogene similar to part of protein phosphatase 6, catalytic subunit (PPP6C) | | | | | Human | | name | gene, processed_pseudogene |
| 2293110 | PPP6CP | protein phosphatase 6 catalytic subunit pseudogene | | X | 109638114 | 109638588 | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1322857 | PPP6R1 | protein phosphatase 6 regulatory subunit 1 | Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phospha tase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010] | 19 | 55228218 | 55259017 | Human | 74 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1316164 | PPP6R3 | protein phosphatase 6 regulatory subunit 3 | Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phospha tase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010] | 11 | 68460752 | 68615334 | Human | 93 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605834 | TIPRL | TOR signaling pathway regulator | TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010] | 1 | 168178962 | 168202109 | Human | 74 | description | gene, protein-coding, VALIDATED [RefSeq] |
