| 621565 | Plb1 | phospholipase B1 | ENCODES a protein that exhibits A2-type glycerophospholipase activity; phosphatidylcholine lysophospholipase A1 activity; retinyl-palmitate esterase activity; INVOLVED IN diacylglycerol catabolic process; phosphatidylcholine catabolic process; phosphatidylethanolamine catabolic process; PARTICIPATES IN retinol metabolic pathway; alpha-linolenic acid metabolic pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH prostate cancer (ortholog); rheumatoid arthritis (ortholog); FOUND IN brush border membrane; INTERACTS WITH ammonium chloride; bisphenol A; copper atom | 6 | 29807127 | 29945607 | Rat | 108 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1346755 | PLB1 | phospholipase B1 | This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016] | 2 | 28496060 | 28644142 | Human | 110 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1616210 | Plb1 | phospholipase B1 | Predicted to enable carboxylic ester hydrolase activity. Acts upstream of or within positive regulation of acrosome reaction. Predicted to be located in apical plasma membrane. Predicted to be active in brush border membrane. Is expressed in diencephalon lateral wall mantle layer; hypothalamus mantl e layer; lung; midbrain mantle layer; and telencephalon mantle layer. Orthologous to human PLB1 (phospholipase B1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 32390035 | 32521700 | Mouse | 122 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9024105 | Plb1 | phospholipase B1 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); calcium-independent phospholipase A2 activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN diacylglycerol catabolic process (ortholog); phosphatidylcholine catabolic process (or tholog); phosphatidylethanolamine catabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH prostate cancer (ortholog); rheumatoid arthritis (ortholog); FOUND IN brush border membrane (ortholog) | NW_004955469 | 10370646 | 10511263 | Chinchilla | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11805185 | PLB1 | phospholipase B1 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); calcium-independent phospholipase A2 activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN diacylglycerol catabolic process (ortholog); phosphatidylcholine catabolic process (or tholog); phosphatidylethanolamine catabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH prostate cancer (ortholog); rheumatoid arthritis (ortholog); FOUND IN brush border membrane (ortholog) | 2A | 28502449 | 28650348 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12074584 | PLB1 | phospholipase B1 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); calcium-independent phospholipase A2 activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN diacylglycerol catabolic process (ortholog); phosphatidylcholine catabolic process (or tholog); phosphatidylethanolamine catabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH prostate cancer (ortholog); rheumatoid arthritis (ortholog); FOUND IN brush border membrane (ortholog) | 17 | 22420679 | 22558318 | Dog | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12495943 | Plb1 | phospholipase B1 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); calcium-independent phospholipase A2 activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN diacylglycerol catabolic process (ortholog); phosphatidylcholine catabolic process (or tholog); phosphatidylethanolamine catabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH prostate cancer (ortholog); rheumatoid arthritis (ortholog); FOUND IN brush border membrane (ortholog) | NW_004936493 | 4112632 | 4210882 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18458733 | PLB1 | phospholipase B1 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); calcium-independent phospholipase A2 activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN diacylglycerol catabolic process (ortholog); phosphatidylcholine catabolic process (or tholog); phosphatidylethanolamine catabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH prostate cancer (ortholog); rheumatoid arthritis (ortholog); FOUND IN brush border membrane (ortholog) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626074867 | Plb1 | phospholipase B1 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); calcium-independent phospholipase A2 activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN diacylglycerol catabolic process (ortholog); phosphatidylcholine catabolic process (or tholog); phosphatidylethanolamine catabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH prostate cancer (ortholog); rheumatoid arthritis (ortholog); FOUND IN brush border membrane (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14274315 | PLB1 | phospholipase B1 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); calcium-independent phospholipase A2 activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN diacylglycerol catabolic process (ortholog); phosphatidylcholine catabolic process (or tholog); phosphatidylethanolamine catabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH prostate cancer (ortholog); rheumatoid arthritis (ortholog); FOUND IN brush border membrane (ortholog) | | | | Pig | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14384386 | PLB1 | | | | | | Yeast | | symbol | gene, null |
| 18913981 | Plb1 | phospholipase B1 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); calcium-independent phospholipase A2 activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN diacylglycerol catabolic process (ortholog); phosphatidylcholine catabolic process (or tholog); phosphatidylethanolamine catabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH prostate cancer (ortholog); rheumatoid arthritis (ortholog); FOUND IN brush border membrane (ortholog) | | | | Naked Mole-Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253136 | plb1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |