| 61949 | Pla2g1b | phospholipase A2 group IB | ENCODES a protein that exhibits A2-type glycerophospholipase activity; signaling receptor binding; bile acid binding (ortholog); INVOLVED IN fatty acid biosynthetic process; positive regulation of cell population proliferation; antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); PARTICIPATES IN alpha-linolenic acid metabolic pathway; arachidonic acid metabolic pathway; ether lipid metabolic pathway; ASSOCIATED WITH Insulin Resistance (ortholog); FOUND IN cell surface; secretory granule; extracellular region (ortholog); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol | 12 | 46802932 | 46814511 | Rat | 151 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62242 | Pla2g1b | phospholipase A2, group IB, pancreas | Enables phospholipase A2 activity and signaling receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; glycerophospholipid metabolic process; and positive regulation of podocyte apoptotic process. Predicted to act upstream of or within phospholipid catabolic process. Located in extracellular region. Is expressed in liver; lung; and spleen. Orthologous to human PLA2G1B (phospholipase A2 group IB). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 115604201 | 115612781 | Mouse | 176 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 735909 | PLA2G1B | phospholipase A2 group IB | This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophosphol ipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013] | 12 | 120322115 | 120327779 | Human | 138 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8881765 | Pla2g1b | phospholipase A2 group IB | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); bile acid binding (ortholog); calcium ion binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); arachidonate secretion (ortholog); cellular response to insu lin stimulus (ortholog); ASSOCIATED WITH Insulin Resistance (ortholog); FOUND IN cell surface (ortholog); extracellular region (ortholog); extracellular space (ortholog) | NW_004955455 | 11308848 | 11316245 | Chinchilla | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11976093 | PLA2G1B | phospholipase A2 group IB | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); bile acid binding (ortholog); INVOLVED IN arachidonate secretion (ortholog); cellular response to insulin stimulus (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Insulin Resistance (ortholog) ; FOUND IN secretory granule (ortholog) | 12 | 117896729 | 117900946 | Bonobo | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12215508 | PLA2G1B | phospholipase A2 group IB | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); bile acid binding (ortholog); INVOLVED IN arachidonate secretion (ortholog); cellular response to insulin stimulus (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Insulin Resistance (ortholog) ; FOUND IN secretory granule (ortholog) | 26 | 16248417 | 16257163 | Dog | 57 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12718283 | Pla2g1b | phospholipase A2 group IB | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); bile acid binding (ortholog); INVOLVED IN arachidonate secretion (ortholog); cellular response to insulin stimulus (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Insulin Resistance (ortholog) ; FOUND IN secretory granule (ortholog) | NW_004936668 | 608848 | 616982 | Squirrel | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18498146 | PLA2G1B | phospholipase A2 group IB | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); bile acid binding (ortholog); INVOLVED IN arachidonate secretion (ortholog); cellular response to insulin stimulus (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Insulin Resistance (ortholog) ; FOUND IN secretory granule (ortholog) | | | | Green Monkey | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915455 | Pla2g1b | phospholipase A2 group IB | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); bile acid binding (ortholog); INVOLVED IN arachidonate secretion (ortholog); cellular response to insulin stimulus (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Insulin Resistance (ortholog) ; FOUND IN secretory granule (ortholog) | | | | Naked Mole-Rat | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626044541 | Pla2g1b | phospholipase A2 group IB | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); bile acid binding (ortholog); calcium ion binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); arachidonate secretion (ortholog); cellular response to insu lin stimulus (ortholog); ASSOCIATED WITH Insulin Resistance (ortholog); FOUND IN cell surface (ortholog); extracellular region (ortholog); extracellular space (ortholog) | | | | Black Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241825 | pla2g1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14000400 | PLA2G1B | phospholipase A2 group IB | ENCODES a protein that exhibits A2-type glycerophospholipase activity; bile acid binding; signaling receptor binding; INVOLVED IN arachidonate secretion; cellular response to insulin stimulus; fatty acid biosynthetic process; ASSOCIATED WITH Insulin Resistance (ortholog); FOUND IN cell surface; secr etory granule (ortholog); INTERACTS WITH acetylsalicylic acid; melittin; prostaglandin E2 | | | | Pig | 71 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155241824 | pla2g1b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243012 | pla2g1b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 284175348 | pla2g1bl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 1560824 | Pla2g1bl1 | phospholipase A2 group IB like 1 | | 6 | 106411255 | 106411855 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 284174542 | pla2g1bl.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1558543 | Pla2r1 | phospholipase A2 receptor 1 | Enables phospholipase binding activity. Involved in negative regulation of phospholipase A2 activity; receptor-mediated endocytosis; and regulation of arachidonate secretion. Located in extracellular region. Is expressed in central nervous system and sensory organ. Orthologous to human PLA2R1 (phosp holipase A2 receptor 1). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 60247887 | 60383669 | Mouse | 113 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |