| 1303213 | Pgap1 | post-GPI attachment to proteins inositol deacylase 1 | ENCODES a protein that exhibits deacylase activity; INVOLVED IN GPI anchor biosynthetic process; positive regulation of ER to Golgi vesicle-mediated transport; anterior/posterior axis specification (ortholog); PARTICIPATES IN glycosylphosphatidylinositol anchor biosynthetic pathway; ASSOCIATED WITH autosomal recessive intellectual developmental disorder 58 (ortholog); Cerebral Visual Impairment and Intellectual Disability (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 9 | 63470023 | 63538772 | Rat | 137 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1605037 | PGAP1 | post-GPI attachment to proteins inositol deacylase 1 | The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause an autosomal recessive form of cognitive impairment. [provided by RefSeq, Jul 2017] | 2 | 196833004 | 196926707 | Human | 236 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1619812 | Pgap1 | post-GPI attachment to proteins 1 | Predicted to enable phosphatidylinositol deacylase activity. Acts upstream of or within embryonic pattern specification; regionalization; and sensory perception of sound. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in sever al structures, including brain; genitourinary system; and neural ectoderm. Used to study holoprosencephaly. Orthologous to human PGAP1 (post-GPI attachment to proteins inositol deacylase 1). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 54512159 | 54596843 | Mouse | 225 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8706948 | Pgap1 | post-GPI attachment to proteins inositol deacylase 1 | ENCODES a protein that exhibits deacylase activity (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); embryonic pattern specification (ortholog); forebrain regionalization (ortholog); ASSOCIATED WITH autosomal recessive intellectual developmental disorder 58 (ortholog); Cerebr al Visual Impairment and Intellectual Disability (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | NW_004955403 | 3527398 | 3582004 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11915142 | PGAP1 | post-GPI attachment to proteins inositol deacylase 1 | ENCODES a protein that exhibits deacylase activity (inferred); hydrolase activity (inferred); hydrolase activity, acting on ester bonds (inferred); INVOLVED IN anterior/posterior axis specification (ortholog); embryonic pattern specification (ortholog); forebrain regionalization (ortholog); ASSOCIAT ED WITH autosomal recessive intellectual developmental disorder 58 (ortholog); Cerebral Visual Impairment and Intellectual Disability (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | 2B | 84076945 | 84166385 | Bonobo | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12295316 | PGAP1 | post-GPI attachment to proteins inositol deacylase 1 | ENCODES a protein that exhibits deacylase activity (inferred); hydrolase activity (inferred); hydrolase activity, acting on ester bonds (inferred); INVOLVED IN anterior/posterior axis specification (ortholog); embryonic pattern specification (ortholog); forebrain regionalization (ortholog); ASSOCIAT ED WITH autosomal recessive intellectual developmental disorder 58 (ortholog); Cerebral Visual Impairment and Intellectual Disability (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | 37 | 6430344 | 6499310 | Dog | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12440003 | Pgap1 | post-GPI attachment to proteins inositol deacylase 1 | ENCODES a protein that exhibits deacylase activity (inferred); hydrolase activity (inferred); hydrolase activity, acting on ester bonds (inferred); INVOLVED IN anterior/posterior axis specification (ortholog); embryonic pattern specification (ortholog); forebrain regionalization (ortholog); ASSOCIAT ED WITH autosomal recessive intellectual developmental disorder 58 (ortholog); Cerebral Visual Impairment and Intellectual Disability (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | NW_004936506 | 2224598 | 2297022 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13976282 | PGAP1 | post-GPI attachment to proteins inositol deacylase 1 | ENCODES a protein that exhibits deacylase activity (inferred); hydrolase activity (inferred); hydrolase activity, acting on ester bonds (inferred); INVOLVED IN anterior/posterior axis specification (ortholog); embryonic pattern specification (ortholog); forebrain regionalization (ortholog); ASSOCIAT ED WITH autosomal recessive intellectual developmental disorder 58 (ortholog); Cerebral Visual Impairment and Intellectual Disability (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | | | | Pig | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18589839 | PGAP1 | post-GPI attachment to proteins inositol deacylase 1 | ENCODES a protein that exhibits deacylase activity (inferred); hydrolase activity (inferred); hydrolase activity, acting on ester bonds (inferred); INVOLVED IN anterior/posterior axis specification (ortholog); embryonic pattern specification (ortholog); forebrain regionalization (ortholog); ASSOCIAT ED WITH autosomal recessive intellectual developmental disorder 58 (ortholog); Cerebral Visual Impairment and Intellectual Disability (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | | | | Green Monkey | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 329332795 | pgap1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14375497 | PGAP1 | | | | | | Fly | | symbol | gene, null |
| 18917399 | Pgap1 | post-GPI attachment to proteins inositol deacylase 1 | ENCODES a protein that exhibits deacylase activity (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); embryonic pattern specification (ortholog); forebrain regionalization (ortholog); ASSOCIATED WITH autosomal recessive intellectual developmental disorder 58 (ortholog); Cerebr al Visual Impairment and Intellectual Disability (ortholog); genetic disease (ortholog); FOUND IN endomembrane system (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 329332797 | pgap1.L | | | | | | African Clawed Frog | | symbol | gene, null |
