| 1348906 | OAS2 | 2'-5'-oligoadenylate synthetase 2 | This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5 As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] | 12 | 112978519 | 113011723 | Human | 186 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1359697 | Oas2 | 2'-5' oligoadenylate synthetase 2 | ENCODES a protein that exhibits 2'-5'-oligoadenylate synthetase activity (ortholog); ATP binding (ortholog); double-stranded RNA binding (ortholog); INVOLVED IN defense response to virus (ortholog); interleukin-27-mediated signaling pathway (ortholog); positive regulation of interferon-beta producti on (ortholog); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; ASSOCIATED WITH Human Influenza (ortholog); FOUND IN cytoplasm (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate | 12 | 41464568 | 41492036 | Rat | 192 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1553377 | Oas2 | 2'-5' oligoadenylate synthetase 2 | Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Involved in cytokine-mediated signaling pathway; defense response to virus; and regulation of lactation. Acts upstream of or within RNA catabolic process and response to bacterium. Predicted to be located in p erinuclear region of cytoplasm. Predicted to be active in cytosol; membrane; and nucleoplasm. Is expressed in embryo. Orthologous to human OAS2 (2'-5'-oligoadenylate synthetase 2). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 120868398 | 120887949 | Mouse | 194 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8868845 | Oas2 | 2'-5'-oligoadenylate synthetase 2 | ENCODES a protein that exhibits 2'-5'-oligoadenylate synthetase activity (ortholog); ATP binding (ortholog); double-stranded RNA binding (ortholog); INVOLVED IN defense response to virus (ortholog); interleukin-27-mediated signaling pathway (ortholog); positive regulation of interferon-beta producti on (ortholog); ASSOCIATED WITH Human Influenza (ortholog); FOUND IN cytoplasm (ortholog); perinuclear region of cytoplasm (ortholog) | NW_004955482 | 9365400 | 9386314 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12401231 | OAS2 | 2'-5'-oligoadenylate synthetase 2 | ENCODES a protein that exhibits 2'-5'-oligoadenylate synthetase activity (inferred); ATP binding (inferred); double-stranded RNA binding (inferred); INVOLVED IN response to bacterium (ortholog); RNA catabolic process (ortholog); ASSOCIATED WITH Human Influenza (ortholog); FOUND IN cytoplasm (inferre d); perinuclear region of cytoplasm (inferred) | 26 | 10431881 | 10450085 | Dog | 32 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626075308 | Oas2 | 2'-5'-oligoadenylate synthetase 2 | ENCODES a protein that exhibits 2'-5'-oligoadenylate synthetase activity (ortholog); ATP binding (ortholog); double-stranded RNA binding (ortholog); INVOLVED IN defense response to virus (ortholog); interleukin-27-mediated signaling pathway (ortholog); positive regulation of interferon-beta producti on (ortholog); ASSOCIATED WITH Human Influenza (ortholog); FOUND IN cytoplasm (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 329868961 | OAS2 | 2'-5'-oligoadenylate synthetase 2 | ENCODES a protein that exhibits 2'-5'-oligoadenylate synthetase activity (inferred); ATP binding (inferred); double-stranded RNA binding (inferred); INVOLVED IN response to bacterium (ortholog); RNA catabolic process (ortholog); ASSOCIATED WITH Human Influenza (ortholog); FOUND IN cytoplasm (inferre d); cytosol (inferred); membrane (inferred) | | | | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14200464 | OAS2 | 2'-5'-oligoadenylate synthetase 2 | ENCODES a protein that exhibits 2'-5'-oligoadenylate synthetase activity (inferred); ATP binding (inferred); double-stranded RNA binding (inferred); INVOLVED IN regulation of lactation (ortholog); response to bacterium (ortholog); RNA catabolic process (ortholog); ASSOCIATED WITH Human Influenza (or tholog); FOUND IN cytoplasm (inferred); perinuclear region of cytoplasm (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 31 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18358102 | OAS2 | 2'-5'-oligoadenylate synthetase 2 | ENCODES a protein that exhibits 2'-5'-oligoadenylate synthetase activity (inferred); ATP binding (inferred); double-stranded RNA binding (inferred); INVOLVED IN response to bacterium (ortholog); RNA catabolic process (ortholog); ASSOCIATED WITH Human Influenza (ortholog); FOUND IN cytoplasm (inferre d); cytosol (inferred); membrane (inferred) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904990 | Oas2 | 2'-5'-oligoadenylate synthetase 2 | ENCODES a protein that exhibits ATP binding (ortholog); INVOLVED IN interleukin-27-mediated signaling pathway (ortholog); positive regulation of interferon-beta production (ortholog); positive regulation of tumor necrosis factor production (ortholog); ASSOCIATED WITH Human Influenza (ortholog); FOUN D IN perinuclear region of cytoplasm (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12021884 | OAS3 | 2'-5'-oligoadenylate synthetase 3 | ENCODES a protein that exhibits 2'-5'-oligoadenylate synthetase activity (inferred); ATP binding (inferred); double-stranded RNA binding (inferred); INVOLVED IN regulation of ribonuclease activity (ortholog); ASSOCIATED WITH Hirschsprung's disease (ortholog); Human Influenza (ortholog); FOUND IN cyt oplasm (inferred); cytosol (inferred); membrane (inferred) | 12 | 110543522 | 110578463 | Bonobo | 48 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12682758 | Oas3 | 2'-5'-oligoadenylate synthetase 3 | ENCODES a protein that exhibits 2'-5'-oligoadenylate synthetase activity (inferred); ATP binding (inferred); double-stranded RNA binding (inferred); INVOLVED IN regulation of ribonuclease activity (ortholog); ASSOCIATED WITH Hirschsprung's disease (ortholog); Human Influenza (ortholog); FOUND IN cyt oplasm (inferred); cytosol (inferred); membrane (inferred) | NW_004936668 | 2917978 | 2965336 | Squirrel | 50 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16561323 | AC004551.1 | novel transcript, antisense to OAS1, OAS2 and OAS3 | | | | | Human | | name | gene, lncrna |