Oas1b Gene Search Result

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
708393	Oas1b	2-5 oligoadenylate synthetase 1B	ENCODES a protein that exhibits 2'-5'-oligoadenylate synthetase activity (ortholog); double-stranded RNA binding (ortholog); INVOLVED IN negative regulation of viral genome replication (ortholog); response to virus (ortholog); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway ... (more) ; FOUND IN endoplasmic reticulum membrane (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine	12	41385184	41395891	Rat	50	symbol , PhenoGen	gene, protein-coding, PROVISIONAL [RefSeq]
1556928	Oas1b	2'-5' oligoadenylate synthetase 1B	This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligome ... (more) rizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]	5	120950700	120962228	Mouse	80	symbol , PhenoGen	gene, protein-coding, REVIEWED [RefSeq]
733565	Oas1g	2'-5' oligoadenylate synthetase 1G	This gene encodes a member of the oligoadenylate synthetase family of proteins. This gene and several other family members are present in a gene cluster on chromosome 5. These proteins are believed to function in antiviral immunity through binding to viral dsRNA and subsequent synthesis of 2'-5'-oli ... (more) goadenylates. The expression of this gene has been shown to be induced by interferon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]	5	121014205	121025676	Mouse	244	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]