Nsmce2 Gene Search Result

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14 records found for search term Nsmce2

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1305156	Nsmce2	NSE2 SUMO ligase component of SMC5/6 complex	ENCODES a protein that exhibits SUMO transferase activity (ortholog); INVOLVED IN cellular senescence (ortholog); double-strand break repair via homologous recombination (ortholog); double-strand break repair via nonhomologous end joining (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Desbuq ... (more) uois dysplasia (ortholog); Developmental Disabilities (ortholog); FOUND IN chromosome, telomeric region (ortholog); nuclear body (ortholog); nucleoplasm (ortholog); INTERACTS WITH bisphenol A; Cuprizon; finasteride	7	92825568	93071037	Rat	119	symbol , PhenoGen	gene, protein-coding, PROVISIONAL [RefSeq]
1331905	Nsmce2	NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase	Predicted to enable SUMO ligase activity. Predicted to be involved in several processes, including DNA recombination; positive regulation of cell cycle process; and protein sumoylation. Predicted to be located in PML body and chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. P ... (more) redicted to be active in nucleus. Is expressed in brain; cerebral cortex ventricular layer; spermatocyte; and testis. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Jul 2025]	15	59246047	59473538	Mouse	159	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1606915	NSMCE2	NSE2 SUMO ligase component of SMC5/6 complex	This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of ch ... (more) romosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]	8	125091860	125367120	Human	199	symbol , old_gene_name , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
8748668	Nsmce2	NSE2 SUMO ligase component of SMC5/6 complex	ENCODES a protein that exhibits SUMO transferase activity (ortholog); INVOLVED IN cellular senescence (ortholog); double-strand break repair via homologous recombination (ortholog); double-strand break repair via nonhomologous end joining (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Desbuq ... (more) uois dysplasia (ortholog); Developmental Disabilities (ortholog); FOUND IN chromosome, telomeric region (ortholog); nuclear body (ortholog); nucleoplasm (ortholog)	NW_004955461	199356	451716	Chinchilla	21	symbol	gene, protein-coding, MODEL [RefSeq]
11836819	NSMCE2	NSE2 SUMO ligase component of SMC5/6 complex	ENCODES a protein that exhibits metal ion binding (inferred); SUMO ligase activity (inferred); SUMO transferase activity (inferred); INVOLVED IN double-strand break repair via nonhomologous end joining (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Desbuquois dysplasia (ortholog); Developmen ... (more) tal Disabilities (ortholog); FOUND IN chromosome, telomeric region (inferred); nuclear body (inferred); nucleoplasm (inferred)	8	121777986	122052094	Bonobo	40	symbol	gene, protein-coding, MODEL [RefSeq]
12434976	NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase	ENCODES a protein that exhibits metal ion binding (inferred); SUMO transferase activity (inferred); transferase activity (inferred); INVOLVED IN double-strand break repair via nonhomologous end joining (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Desbuquois dysplasia (ortholog); Developmen ... (more) tal Disabilities (ortholog); FOUND IN chromosome, telomeric region (inferred); nuclear body (inferred); nucleoplasm (inferred)	13	23078143	23288302	Dog	41	symbol	gene, protein-coding, MODEL [RefSeq]
12628640	Nsmce2	NSE2 SUMO ligase component of SMC5/6 complex	ENCODES a protein that exhibits metal ion binding (inferred); SUMO ligase activity (inferred); SUMO transferase activity (inferred); INVOLVED IN double-strand break repair via nonhomologous end joining (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Desbuquois dysplasia (ortholog); Developmen ... (more) tal Disabilities (ortholog); FOUND IN chromosome, telomeric region (inferred); nuclear body (inferred); nucleoplasm (inferred)	NW_004936470	22447278	22667302	Squirrel	42	symbol	gene, protein-coding, MODEL [RefSeq]
14063137	NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase	ENCODES a protein that exhibits ligase activity (inferred); metal ion binding (inferred); SUMO transferase activity (inferred); INVOLVED IN double-strand break repair via nonhomologous end joining (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Desbuquois dysplasia (ortholog); Developmental D ... (more) isabilities (ortholog); FOUND IN chromosome, telomeric region (inferred); nuclear body (inferred); nucleoplasm (inferred)				Pig	43	symbol	gene, protein-coding, MODEL [RefSeq]
18487819	NSMCE2	NSE2 SUMO ligase component of SMC5/6 complex	ENCODES a protein that exhibits metal ion binding (inferred); SUMO ligase activity (inferred); SUMO transferase activity (inferred); INVOLVED IN double-strand break repair via nonhomologous end joining (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Desbuquois dysplasia (ortholog); Developmen ... (more) tal Disabilities (ortholog); FOUND IN chromosome, telomeric region (inferred); nuclear body (inferred); nucleoplasm (inferred)				Green Monkey	39	symbol	gene, protein-coding, MODEL [RefSeq]
288081916	nsmce2						Tropical Clawed Frog		symbol	gene, null
18917056	Nsmce2	NSE2 SUMO ligase component of SMC5/6 complex	ENCODES a protein that exhibits ligase activity (inferred); metal ion binding (inferred); SUMO ligase activity (inferred); INVOLVED IN cellular senescence (ortholog); double-strand break repair via nonhomologous end joining (ortholog); positive regulation of maintenance of mitotic sister chromatid c ... (more) ohesion (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Desbuquois dysplasia (ortholog); Developmental Disabilities (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog)				Naked Mole-Rat	38	symbol	gene, protein-coding, MODEL [RefSeq]
625982348	Nsmce2	NSE2 SUMO ligase component of SMC5/6 complex	ENCODES a protein that exhibits SUMO transferase activity (ortholog); INVOLVED IN cellular senescence (ortholog); double-strand break repair via homologous recombination (ortholog); double-strand break repair via nonhomologous end joining (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Desbuq ... (more) uois dysplasia (ortholog); Developmental Disabilities (ortholog); FOUND IN chromosome, telomeric region (ortholog); nuclear body (ortholog); nucleoplasm (ortholog)				Black Rat	21	symbol	gene, protein-coding, MODEL [RefSeq]
288081972	nsmce2.L						African Clawed Frog		symbol	gene, null
1593783	Nsmce2-ps2	NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase, pseudogene 2		10	64284087	64288698	Rat		symbol , PhenoGen	gene, pseudo, MODEL [RefSeq]