| 708549 | Nlrp6 | NLR family, pyrin domain containing 6 | ENCODES a protein that exhibits peptide binding; vasopressin receptor activity; double-stranded RNA binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); acute inflammatory response to antigenic stimulus (ortholog); antiviral innate immune response (ortholog); FOUND IN canonical in flammasome complex (ortholog); cytosol (ortholog); NLRP6 inflammasome complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A | 1 | 205434484 | 205441245 | Rat | 174 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1350327 | NLRP6 | NLR family pyrin domain containing 6 | The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013] | 11 | 278407 | 285388 | Human | 125 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552887 | Nlrp6 | NLR family, pyrin domain containing 6 | The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. [provided by RefSeq, Feb 2013] | 7 | 140500777 | 140509105 | Mouse | 188 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8817367 | Nlrp6 | NLR family pyrin domain containing 6 | ENCODES a protein that exhibits double-stranded RNA binding (ortholog); lipopolysaccharide binding (ortholog); lipoteichoic acid binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); acute inflammatory response to antigenic stimulus (ortholog); antiviral innate immune response (ort holog); FOUND IN canonical inflammasome complex (ortholog); cytosol (ortholog); NLRP6 inflammasome complex (ortholog) | NW_004955476 | 11755489 | 11762781 | Chinchilla | 55 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 11861959 | NLRP6 | NLR family pyrin domain containing 6 | ENCODES a protein that exhibits peptide binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); acute inflammatory response to antigenic stimulus (ortholog); host-mediated modulation of intestinal microbiota composition (ortholog); FOUND IN canonical inflammasome complex (inferred); cytoplasm (inferred); cytosol (inferred) | 11 | 274904 | 281590 | Bonobo | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12356442 | NLRP6 | NLR family pyrin domain containing 6 | ENCODES a protein that exhibits peptide binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); acute inflammatory response to antigenic stimulus (ortholog); host-mediated modulation of intestinal microbiota composition (ortholog); FOUND IN canonical inflammasome complex (inferred); cytosol (inferred); NLRP6 inflammasome complex (inferred) | 18 | 25433481 | 25440703 | Dog | 57 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 12461129 | Nlrp6 | NLR family pyrin domain containing 6 | ENCODES a protein that exhibits peptide binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); acute inflammatory response to antigenic stimulus (ortholog); host-mediated modulation of intestinal microbiota composition (ortholog); FOUND IN canonical inflammasome complex (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936888 | 145642 | 151716 | Squirrel | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866743 | NLRP6 | NLR family pyrin domain containing 6 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 18475807 | NLRP6 | NLR family pyrin domain containing 6 | ENCODES a protein that exhibits peptide binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); acute inflammatory response to antigenic stimulus (ortholog); host-mediated modulation of intestinal microbiota composition (ortholog); FOUND IN canonical inflammasome complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 152178124 | NLRP6 | NLR family pyrin domain containing 6 | | | | | Naked Mole-Rat | | symbol | gene, protein-coding |
| 626098973 | Nlrp6 | NLR family pyrin domain containing 6 | ENCODES a protein that exhibits double-stranded RNA binding (ortholog); lipopolysaccharide binding (ortholog); lipoteichoic acid binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); acute inflammatory response to antigenic stimulus (ortholog); antiviral innate immune response (ort holog); FOUND IN canonical inflammasome complex (ortholog); cytosol (ortholog); NLRP6 inflammasome complex (ortholog) | | | | Black Rat | 55 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 14264957 | NLRP6 | NLR family pyrin domain containing 6 | ENCODES a protein that exhibits peptide binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); acute inflammatory response to antigenic stimulus (ortholog); host-mediated modulation of intestinal microbiota composition (ortholog); FOUND IN canonical inflammasome complex (inferred); cytosol (inferred); membrane (inferred) | | | | Pig | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18916535 | Nlrp6 | NLR family pyrin domain containing 6 | ENCODES a protein that exhibits double-stranded RNA binding (ortholog); lipopolysaccharide binding (ortholog); lipoteichoic acid binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); acute inflammatory response to antigenic stimulus (ortholog); antiviral innate immune response (ort holog); FOUND IN cytosol (ortholog); NLRP6 inflammasome complex (ortholog) | | | | Naked Mole-Rat | 62 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 1553376 | Pycard | PYD and CARD domain containing | Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of cytokine production; and regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of macrophage cytokine production; and regulation of autophagy. Located in cytosol; extracellular region; and nucleus. Part of NLRP6 inflammasome complex. Is expressed in several structures, including alimentary system; brain; heart; hemolymphoid system gland; and urinary system. Orthologous to human PYCARD (PYD and CARD domain containing). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 127590545 | 127593039 | Mouse | 720 | description | gene, protein-coding, VALIDATED [RefSeq] |